Pleomorphic Liposarcoma Arising in a Lipoleiomyosarcoma of the Uterus: Report of a Case With Genetic Profiling by a Next Generation Sequencing Panel

Overview

Journal Int J Gynecol Pathol

Specialties Gynecology & Obstetrics
Pathology

Date 2015 Nov 25

PMID 26598981

Citations 5

Authors

J Kenneth Schoolmeester

Michael D Stamatakos

Ann M Moyer

Kay J Park

Melissa Fairbairn

Amanda N Fader

Affiliations

Soon will be listed here.

Abstract

Uterine tumors with adipocytic differentiation are very uncommon. Mature adipocytes are sometimes seen as an element of smooth muscle neoplasms, more often as lipoleiomyoma, but also in the rare lipoleiomyosarcoma. Exceptional cases have been reported of various subtypes of liposarcoma associated with uterine smooth muscle tumors with or without adipocytic differentiation. We present a case of pleomorphic liposarcoma arising in a lipoleiomyosarcoma of the uterus. Genomic profiling was performed using a validated next generation sequencing panel covering 410 common cancer genes. Alterations were identified in TP53, PTEN, RB1, FAT1 and TERT. The patient's presentation and clinical course as well as the tumor's morphologic, immunohistochemical and molecular genetic findings are reviewed.

Citing Articles

Dedifferentiated recurrent liposarcoma of the uterine corpus: A case report and literature review.

Mushtaq S, Hassan M, Li Y, Abdi I, Ahmad A, Li H Case Rep Womens Health. 2024; 44:e00670.

PMID: 39659618 PMC: 11629544. DOI: 10.1016/j.crwh.2024.e00670.

Lipoleiomyosarcoma with pleomorphic liposarcoma of the uterus: Computed tomography findings with pathological correlation. A case report and review of literature.

Arpaia V, Pirolo L, Sfregola S, Licata L, Iovino M, Sanduzzi L Radiol Case Rep. 2024; 19(11):5474-5480.

PMID: 39285970 PMC: 11403635. DOI: 10.1016/j.radcr.2024.08.004.

Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature.

Hoshino T, Takada Y, Sugihara A, Kinugasa M, Tsuji Y Case Rep Obstet Gynecol. 2024; 2024:7599714.

PMID: 38435759 PMC: 10908573. DOI: 10.1155/2024/7599714.

PLAG1-rearrangment in a uterine leiomyosarcoma with myxoid stroma and heterologous differentiation.

Thiryayi S, Turashvili G, Latta E, Swanson D, Zhang L, Antonescu C Genes Chromosomes Cancer. 2021; 60(10):713-717.

PMID: 34184333 PMC: 9121515. DOI: 10.1002/gcc.22980.

Liposarcoma of the uterine corpus: A case report and literature review.

Kiuchi K, Hasegawa K, Ochiai S, Kosaka N, Kuroda H, Kaji Y Gynecol Oncol Rep. 2018; 26:78-81.

PMID: 30386812 PMC: 6205323. DOI: 10.1016/j.gore.2018.10.008.

References

Fadare O, Khabele D . Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. Int J Gynecol Pathol. 2011; 30(3):282-7. DOI: 10.1097/PGP.0b013e31820086a4. View

Aung T, Goto M, Nomoto M, Kitajima S, Douchi T, Yoshinaga M . Uterine lipoleiomyoma: a histopathological review of 17 cases. Pathol Int. 2004; 54(10):751-8. DOI: 10.1111/j.1440-1827.2004.01748.x. View

Nicolas M, Tamboli P, Gomez J, Czerniak B . Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases. Hum Pathol. 2009; 41(5):663-71. DOI: 10.1016/j.humpath.2009.10.005. View

Koelsche C, Renner M, Hartmann W, Brandt R, Lehner B, Waldburger N . TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities. J Exp Clin Cancer Res. 2014; 33:33. PMC: 4022359. DOI: 10.1186/1756-9966-33-33. View

Cheng D, Mitchell T, Zehir A, Shah R, Benayed R, Syed A . Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. J Mol Diagn. 2015; 17(3):251-64. PMC: 5808190. DOI: 10.1016/j.jmoldx.2014.12.006. View

Tashiro H, Blazes M, Wu R, Cho K, Bose S, Wang S . Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res. 1997; 57(18):3935-40. View

Bapat K, Brustein S . Uterine sarcoma with liposarcomatous differentiation: report of a case and review of the literature. Int J Gynaecol Obstet. 1989; 28(1):71-5. DOI: 10.1016/0020-7292(89)90547-x. View

Idbaih A, Coindre J, Derre J, Mariani O, Terrier P, Ranchere D . Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. Lab Invest. 2005; 85(2):176-81. DOI: 10.1038/labinvest.3700202. View

Ng P, Henikoff S . Predicting deleterious amino acid substitutions. Genome Res. 2001; 11(5):863-74. PMC: 311071. DOI: 10.1101/gr.176601. View

10.

Lee H, Tseng H, Hsieh P, Shih T . Uterine lipoleiomyosarcoma: report of 2 cases and review of the literature. Int J Gynecol Pathol. 2012; 31(4):358-63. DOI: 10.1097/PGP.0b013e31823f841f. View

11.

Cordon-Cardo C, Latres E, Drobnjak M, Oliva M, Pollack D, Woodruff J . Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res. 1994; 54(3):794-9. View

12.

Huang F, Hodis E, Xu M, Kryukov G, Chin L, Garraway L . Highly recurrent TERT promoter mutations in human melanoma. Science. 2013; 339(6122):957-9. PMC: 4423787. DOI: 10.1126/science.1229259. View

13.

Koh W, Greer B, Abu-Rustum N, Apte S, Campos S, Chan J . Uterine neoplasms, version 1.2014. J Natl Compr Canc Netw. 2014; 12(2):248-80. DOI: 10.6004/jnccn.2014.0025. View

14.

Zhai Y, Nikaido T, Orii A, Horiuchi A, Toki T, Fujii S . Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma. Gynecol Oncol. 1999; 75(3):453-9. DOI: 10.1006/gyno.1999.5629. View

15.

Gibault L, Perot G, Chibon F, Bonnin S, Lagarde P, Terrier P . New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics. J Pathol. 2010; 223(1):64-71. DOI: 10.1002/path.2787. View

16.

Doldan A, Otis C, Pantanowitz L . Adipose tissue: a normal constituent of the uterine cervical stroma. Int J Gynecol Pathol. 2009; 28(4):396-400. DOI: 10.1097/PGP.0b013e318192cd20. View