Uterine Lipoleiomyosarcoma: Report of 2 Cases and Review of the Literature

Uterine lipoleiomyosarcoma is a rare entity with only 6 case reports in the Pubmed database at the time of writing this article. We report 2 additional cases of uterine lipoleiomyosarcoma, characterized on microscopy by coexistence of leiomyosarcomatous and liposarcomatous components, with focal intermingling, without an intervening lipoleiomyomatous area. The liposarcomatous component in both of our cases had the morphology of myxoid liposarcoma. Both cases underwent postoperative chemotherapy. One of our cases had recurrence in the pelvis with microscopic features of myxoid liposarcoma. This patient died with multiple metastases 4.5 yr after hysterectomy, with the metastatic lesions being liposarcomas, without an evident leiomyosarcomatous component. Although lacking a treatment protocol because of the rarity of such cases, postoperative adjuvant therapy is mandatory.