Role of the Red Ginseng in Defense Against the Environmental Heat Stress in Sprague Dawley Rats

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2015 Nov 17

PMID 26569207

Citations 9

Authors

Kui-Jin Kim

Kye-Yoon Yoon

Hee-Do Hong

Boo-Yong Lee

Affiliations

Soon will be listed here.

Abstract

Global temperature change causes heat stress related disorders in humans. A constituent of red ginseng has been known the beneficial effect on the resistance to many diseases. However, the mechanism of red ginseng (RG) against heat stress still remains unclear. To determine the effect of RG on heat stress, we examined the effect of the RG on the gene expression profiles in rats subjected to environmental heat stress. We evaluated the transcripts associated with hepatic lipid accumulation and oxidative stress in rats subjected to heat stress. We also analyzed the reactive oxygen species (ROS) contents. Our results suggested RG inhibited heat stress mediated altering mRNA expressions include HSPA1, DEAF1, HMGCR, and FMO1. We also determined RG attenuated fat accumulation in the liver by altering C/EBPβ expression. RG promoted to repress the heat stress mediated hepatic cell death by inhibiting of Bcl-2 expression in rats subjected to heat stress. Moreover, RG administered group during heat stress dramatically decreased the malondialdehyde (MDA) contents and ROS associated genes compared with the control group. Thus, we suggest that RG might influence inhibitory effect on environmental heat stress induced abnormal conditions in humans.

Citing Articles

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Effects of Red Ginseng Byproducts on Rumen Fermentation, Growth Performance, Blood Metabolites, and mRNA Expression of Heat Shock Proteins in Heat-Stressed Fattening Hanwoo Steers.

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Korean Red Ginseng alleviates neuroinflammation and promotes cell survival in the intermittent heat stress-induced rat brain by suppressing oxidative stress via estrogen receptor beta and brain-derived neurotrophic factor upregulation.

Iqbal H, Kim S, Cha K, Jeong M, Ghosh P, Rhee D J Ginseng Res. 2020; 44(4):593-602.

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PMID: 32148408 PMC: 7031738. DOI: 10.1016/j.jgr.2018.12.005.

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