Predicting Disease Onset in Clinically Healthy People

Overview

Journal Interdiscip Toxicol

Specialty Biology

Date 2017 Jun 28

PMID 28652846

Citations 3

Authors

Harold I Zeliger

Affiliations

Soon will be listed here.

Abstract

Virtually all human disease is induced by oxidative stress. Oxidative stress, which is caused by toxic environmental exposure, the presence of disease, lifestyle choices, stress, chronic inflammation or combinations of these, is responsible for most disease. Oxidative stress from all sources is additive and it is the total oxidative stress from all sources that induces the onset of most disease. Oxidative stress leads to lipid peroxidation, which in turn produces Malondialdehyde. Serum malondialdehyde level is an additive parameter resulting from all sources of oxidative stress and, therefore, is a reliable indicator of total oxidative stress which can be used to predict the onset of disease in clinically asymptomatic individuals and to suggest the need for treatment that can prevent much human disease.

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References

Yesilbursa D, Serdar Z, Serdar A, Sarac M, Coskun S, Jale C . Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels. Int J Obes (Lond). 2004; 29(1):142-5. DOI: 10.1038/sj.ijo.0802794. View

Bovalino S, Charleson G, Szoeke C . The impact of red and processed meat consumption on cardiovascular disease risk in women. Nutrition. 2016; 32(3):349-54. DOI: 10.1016/j.nut.2015.09.015. View

Faden A, Loane D . Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?. Neurotherapeutics. 2014; 12(1):143-50. PMC: 4322076. DOI: 10.1007/s13311-014-0319-5. View

Kambia N, Dine T, Gressier B, Frimat B, Cazin J, Luyckx M . Correlation between exposure to phthalates and concentrations of malondialdehyde in infants and children undergoing cyclic parenteral nutrition. JPEN J Parenter Enteral Nutr. 2011; 35(3):395-401. DOI: 10.1177/0148607110381769. View

Falagas M, Kompoti M . Obesity and infection. Lancet Infect Dis. 2006; 6(7):438-46. DOI: 10.1016/S1473-3099(06)70523-0. View

Nousen E, Franco J, Sullivan E . Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders. Neuroendocrinology. 2013; 98(4):254-66. PMC: 4121390. DOI: 10.1159/000355632. View

Pritchard C, Rosenorn-Lanng E . Neurological deaths of American adults (55-74) and the over 75's by sex compared with 20 Western countries 1989-2010: Cause for concern. Surg Neurol Int. 2015; 6:123. PMC: 4521226. DOI: 10.4103/2152-7806.161420. View

Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J . Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003; 111(4):455-60. PMC: 1241427. DOI: 10.1289/ehp.6000. View

Kulkarni R, Deshpande A, Saxena R, Saxena K . A study of serum malondialdehyde and cytokine in tuberculosis patients. J Clin Diagn Res. 2013; 7(10):2140-2. PMC: 3843479. DOI: 10.7860/JCDR/2013/5736.3452. View

10.

Jain S, McVie R, Smith T . Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children. Diabetes Care. 2000; 23(9):1389-94. DOI: 10.2337/diacare.23.9.1389. View

11.

Crous-Bou M, Fung T, Prescott J, Julin B, Du M, Sun Q . Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study. BMJ. 2014; 349:g6674. PMC: 4252824. DOI: 10.1136/bmj.g6674. View

12.

Zeliger H . Lipophilic chemical exposure as a cause of cardiovascular disease. Interdiscip Toxicol. 2013; 6(2):55-62. PMC: 3798856. DOI: 10.2478/intox-2013-0010. View

13.

Meiners S, Eickelberg O, Konigshoff M . Hallmarks of the ageing lung. Eur Respir J. 2015; 45(3):807-27. DOI: 10.1183/09031936.00186914. View

14.

Choi Y, Seelbach M, Pu H, Eum S, Chen L, Zhang B . Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression. Environ Health Perspect. 2010; 118(7):976-81. PMC: 2920918. DOI: 10.1289/ehp.0901751. View

15.

Aryal M, Pandeya A, Gautam N, Baral N, Lamsal M, Majhi S . Oxidative stress in benign prostate hyperplasia. Nepal Med Coll J. 2008; 9(4):222-4. View

16.

Madebo T, Lindtjorn B, Aukrust P, Berge R . Circulating antioxidants and lipid peroxidation products in untreated tuberculosis patients in Ethiopia. Am J Clin Nutr. 2003; 78(1):117-22. DOI: 10.1093/ajcn/78.1.117. View

17.

Knight T, Fariss M, Farhood A, Jaeschke H . Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice. Toxicol Sci. 2003; 76(1):229-36. DOI: 10.1093/toxsci/kfg220. View

18.

Zeliger H . Toxic effects of chemical mixtures. Arch Environ Health. 2003; 58(1):23-9. DOI: 10.3200/AEOH.58.1.23-29. View

19.

Honjo K, van Reekum R, Verhoeff N . Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease?. Alzheimers Dement. 2009; 5(4):348-60. DOI: 10.1016/j.jalz.2008.12.001. View

20.

Kim R, Rhee J, Won E, Lee K, Kang C, Lee Y . Ultraviolet B retards growth, induces oxidative stress, and modulates DNA repair-related gene and heat shock protein gene expression in the monogonont rotifer, Brachionus sp. Aquat Toxicol. 2011; 101(3-4):529-39. DOI: 10.1016/j.aquatox.2010.12.005. View