Adult Astrogenesis and the Etiology of Cortical Neurodegeneration

Overview

Journal J Exp Neurosci

Publisher Sage Publications

Specialty Neurology

Date 2015 Nov 17

PMID 26568684

Citations 19

Authors

Tal C Mohn

Andrew O Koob

Affiliations

Soon will be listed here.

Abstract

As more evidence points to a clear role for astrocytes in synaptic processing, synaptogenesis and cognition, continuing research on astrocytic function could lead to strategies for neurodegenerative disease prevention. Reactive astrogliosis results in astrocyte proliferation early in injury and disease states and is considered neuroprotective, indicating a role for astrocytes in disease etiology. This review describes the different types of human cortical astrocytes and the current evidence regarding adult cortical astrogenesis in injury and degenerative disease. A role for disrupted astrogenesis as a cause of cortical degeneration, with a focus on the tauopathies and synucleinopathies, will also be considered.

Citing Articles

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The Astrogenic Balance in the Aging Brain.

Andromidas F, Atashpanjeh S, Myers A, Mackinnon B, Shaffer M, Koob A Curr Neuropharmacol. 2021; 19(11):1952-1965.

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