PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Nov 12

PMID 26555441

Citations 8

Authors

Ji-Hyun Lee

Kyoung Mii Park

Dong-Jin Han

Nam Young Bang

Do-Hee Kim

Hyeongjin Na

Semi Lim

Tae Bum Kim

Dae Gyu Kim

Hyun-Jung Kim

Yeonseok Chung

Sang Hyun Sung

Young-Joon Surh

Sunghoon Kim

Byung Woo Han

Affiliations

Soon will be listed here.

Abstract

Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org.

Citing Articles

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Literature based discovery of alternative TCM medicine for adverse reactions to depression drugs.

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