Regeneration in the Nervous System with Erythropoietin

Overview

Journal Front Biosci (Landmark Ed)

Specialty Biology

Date 2015 Nov 10

PMID 26549969

Citations 16

Authors

Kenneth Maiese

Affiliations

Soon will be listed here.

Abstract

Globally, greater than 30 million individuals are afflicted with disorders of the nervous system accompanied by tens of thousands of new cases annually with limited, if any, treatment options. Erythropoietin (EPO) offers an exciting and novel therapeutic strategy to address both acute and chronic neurodegenerative disorders. EPO governs a number of critical protective and regenerative mechanisms that can impact apoptotic and autophagic programmed cell death pathways through protein kinase B (Akt), sirtuins, mammalian forkhead transcription factors, and wingless signaling. Translation of the cytoprotective pathways of EPO into clinically effective treatments for some neurodegenerative disorders has been promising, but additional work is necessary. In particular, development of new treatments with erythropoiesis-stimulating agents such as EPO brings several important challenges that involve detrimental vascular outcomes and tumorigenesis. Future work that can effectively and safely harness the complexity of the signaling pathways of EPO will be vital for the fruitful treatment of disorders of the nervous system.

Citing Articles

Innovations in Peripheral Nerve Regeneration.

Lam T, Leung Y Bioengineering (Basel). 2024; 11(5).

PMID: 38790310 PMC: 11118957. DOI: 10.3390/bioengineering11050444.

Innovative therapeutic strategies for cardiovascular disease.

Maiese K EXCLI J. 2023; 22:690-715.

PMID: 37593239 PMC: 10427777. DOI: 10.17179/excli2023-6306.

The Metabolic Basis for Nervous System Dysfunction in Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease.

Maiese K Curr Neurovasc Res. 2023; 20(3):314-333.

PMID: 37488757 PMC: 10528135. DOI: 10.2174/1567202620666230721122957.

Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System.

Maiese K Biomolecules. 2023; 13(5).

PMID: 37238686 PMC: 10216724. DOI: 10.3390/biom13050816.

Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm.

Maiese K Front Biosci (Landmark Ed). 2021; 26(9):614-627.

PMID: 34590471 PMC: 8756734. DOI: 10.52586/4971.

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