Association Between Adiposity and Left Ventricular Mass in Children With Hypertension

Overview

Journal J Clin Hypertens (Greenwich)

Specialty Cardiology & Vascular Diseases

Date 2015 Nov 5

PMID 26530452

Citations 16

Authors

Tammy M Brady

Lawrence J Appel

Kathryn W Holmes

Barbara Fivush

Edgar R Miller 3rd

Affiliations

Soon will be listed here.

Abstract

Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m(2.7) vs 0.95 g/m(2.7) . Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54-6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.

Citing Articles

Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression.

Sinha M, Azukaitis K, Sladowska-Kozlowska J, Bardsen T, Merkevicius K, Sletten I Front Cardiovasc Med. 2022; 9:993513.

PMID: 36386367 PMC: 9659762. DOI: 10.3389/fcvm.2022.993513.

Neutrophil to Lymphocyte Ratio Is Increased and Associated With Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

Hou M, Cao L, Ding Y, Chen Y, Wang B, Shen J Front Pediatr. 2021; 9:576005.

PMID: 34095018 PMC: 8169980. DOI: 10.3389/fped.2021.576005.

Left Ventricular Diastolic Dysfunction Among Youth with Obesity and History of Elevated Blood Pressure.

Abdul-Raheem J, Binka E, Roem J, Turer C, Urbina E, Brady T J Pediatr. 2021; 235:130-137.

PMID: 33812920 PMC: 8383194. DOI: 10.1016/j.jpeds.2021.03.066.

Impact of Pediatric Obesity on Diurnal Blood Pressure Assessment and Cardiovascular Risk Markers.

Murphy M, Huang H, Bauer J, Schadler A, Makhoul M, Clasey J Front Pediatr. 2021; 9:596142.

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Clinical Decision Support for the Diagnosis and Management of Adult and Pediatric Hypertension.

Vuppala S, Turer C Curr Hypertens Rep. 2020; 22(9):67.

PMID: 32852616 PMC: 7450038. DOI: 10.1007/s11906-020-01083-9.

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