Telomere Homeostasis in Mammalian Germ Cells: a Review

Overview

Journal Chromosoma

Specialty Molecular Biology

Date 2015 Nov 4

PMID 26525972

Citations 26

Authors

Rita Reig-Viader

Montserrat Garcia-Caldes

Aurora Ruiz-Herrera

Affiliations

Soon will be listed here.

Abstract

Telomeres protect against genome instability and participate in chromosomal movements during gametogenesis, especially in meiosis. Thus, maintaining telomere structure and telomeric length is essential to both cell integrity and the production of germ cells. As a result, alteration of telomere homeostasis in the germ line may result in the generation of aneuploid gametes or gametogenesis disruption, triggering fertility problems. In this work, we provide an overview on fundamental aspects of the literature regarding the organization of telomeres in mammalian germ cells, paying special attention to telomere structure and function, as well as the maintenance of telomeric length during gametogenesis. Moreover, we discuss the different roles recently described for telomerase and TERRA in maintaining telomere functionality. Finally, we review how new findings in the field of reproductive biology underscore the role of telomere homeostasis as a potential biomarker for infertility. Overall, we anticipate that the study of telomere stability and equilibrium will contribute to improve diagnoses of patients; assess the risk of infertility in the offspring; and in turn, find new treatments.

Citing Articles

Canine sperm motility is associated with telomere shortening and changes in expression of shelterin genes.

Hassanpour H, Mirshokraei P, Salehpour M, Amiri K, Ghareghani P, Nasiri L BMC Vet Res. 2023; 19(1):236.

PMID: 37950187 PMC: 10637008. DOI: 10.1186/s12917-023-03795-x.

TERRA beyond cancer: the biology of telomeric repeat-containing RNAs in somatic and germ cells.

Rivosecchi J, Cusanelli E Front Aging. 2023; 4:1224225.

PMID: 37636218 PMC: 10448526. DOI: 10.3389/fragi.2023.1224225.

Male Germ Cell Telomeres and Chemical Pollutants.

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PMID: 37238614 PMC: 10216011. DOI: 10.3390/biom13050745.

Chromosomal Instability in Genome Evolution: From Cancer to Macroevolution.

Comaills V, Castellano-Pozo M Biology (Basel). 2023; 12(5).

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Mono-(2-ethylhexyl) Phthalate (MEHP)-Induced Telomere Structure and Function Disorder Mediates Cell Cycle Dysregulation and Apoptosis via c-Myc and Its Upstream Transcription Factors in a Mouse Spermatogonia-Derived (GC-1) Cell Line.

Zhou F, Guo C, Wang L, Zhang G, Wang J, Chen W Toxics. 2023; 11(5).

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