Hepatitis D Virus Replication

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2015 Nov 4

PMID 26525452

Citations 27

Authors

John M Taylor

Affiliations

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Abstract

This work reviews specific related aspects of hepatitis delta virus (HDV) reproduction, including virion structure, the RNA genome, the mode of genome replication, the delta antigens, and the assembly of HDV using the envelope proteins of its helper virus, hepatitis B virus (HBV). These topics are considered with perspectives ranging from a history of discovery through to still-unsolved problems. HDV evolution, virus entry, and associated pathogenic potential and treatment of infections are considered in other articles in this collection.

Citing Articles

Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg-IFNα-2a as Treatment for Chronic Hepatitis Delta.

Lampertico P, Bogomolov P, Chulanov V, Stepanova T, Morozov V, Allweiss L Liver Int. 2025; 45(2):e70008.

PMID: 39853842 PMC: 11760647. DOI: 10.1111/liv.70008.

The RNA Revolution in the Central Molecular Biology Dogma Evolution.

Haseltine W, Patarca R Int J Mol Sci. 2024; 25(23).

PMID: 39684407 PMC: 11641533. DOI: 10.3390/ijms252312695.

Chronic Hepatitis D Virus Infection and Its Treatment: A Narrative Review.

Mathur P, Khanam A, Kottilil S Microorganisms. 2024; 12(11).

PMID: 39597566 PMC: 11596900. DOI: 10.3390/microorganisms12112177.

Understanding viroids, endogenous circular RNAs, and viroid-like RNAs in the context of biogenesis.

Hao J, Ma J, Wang Y PLoS Pathog. 2024; 20(6):e1012299.

PMID: 38935625 PMC: 11210808. DOI: 10.1371/journal.ppat.1012299.

Broad-spectrum activity of bulevirtide against clinical isolates of HDV and recombinant pan-genotypic combinations of HBV/HDV.

Mateo R, Xu S, Shornikov A, Yazdi T, Liu Y, May L JHEP Rep. 2023; 5(11):100893.

PMID: 37929228 PMC: 10622701. DOI: 10.1016/j.jhepr.2023.100893.

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