Cortical Asymmetries in Unaffected Siblings of Patients with Obsessive-compulsive Disorder

Overview

Journal Psychiatry Res

Specialty Psychiatry

Date 2015 Nov 3

PMID 26522981

Citations 8

Authors

Ziwen Peng

Gang Li

Feng Shi

Changzheng Shi

Qiong Yang

Raymond C K Chan

Dinggang Shen

Affiliations

Soon will be listed here.

Abstract

Obsessive-compulsive disorder (OCD) is considered to be associated with atypical brain asymmetry. However, no study has examined the asymmetry in OCD from the perspective of cortical morphometry. This study is aimed to describe the characteristics of cortical asymmetry in OCD patients, and to investigate whether these features exist in their unaffected siblings - a vital step in identifying putative endophenotypes for OCD. A total of 48 subjects (16 OCD patients, 16 unaffected siblings, and 16 matched controls) were recruited who had complete magnetic resonance imaging scans. Left-right hemispheric asymmetries of cortical thickness were measured using a surface-based threshold-free cluster enhancement method. OCD patients and siblings both showed leftward asymmetries of cortical thickness in the anterior cingulate cortex (ACC), which showed a significant positive correlation with compulsive subscale scores. In addition, siblings and healthy controls showed significantly decreased leftward asymmetries in the orbitofrontal cortex (OFC), and the decreased leftward bias in the OFC was accompanied by lower scales on the Yale-Brown Obsessive-Compulsive Scale. To sum up, leftward asymmetries of cortical thickness in the ACC may represent an endophenotype of increased hereditary risk for OCD, while decreased leftward asymmetries of cortical thickness in the OFC may represent a protective factor.

Citing Articles

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Abnormal brain functional network dynamics in obsessive-compulsive disorder patients and their unaffected first-degree relatives.

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