Greater Regional Cortical Gray Matter Thickness in Obsessive-compulsive Disorder

Overview

Journal Neuroreport

Specialty Neurology

Date 2008 Sep 18

PMID 18797315

Citations 11

Authors

Veena M Narayan

Katherine L Narr

Owen R Phillips

Paul M Thompson

Arthur W Toga

Philip R Szeszko

Affiliations

Soon will be listed here.

Abstract

Earlier studies are inconsistent regarding the structural basis of obsessive-compulsive disorder (OCD), and few studies have investigated whether patients with OCD have cortical thickness abnormalities compared with healthy volunteers. Using magnetic resonance imaging we compared regional differences in cortical thickness among 21 patients with OCD and 21 demographically matched healthy volunteers. Our findings indicate that the right inferior frontal cortex and posterior middle temporal gyrus are thicker in patients with OCD compared with healthy controls, which may contribute to response inhibition deficits and other aspects of phenomenology related to the disorder.

Citing Articles

Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder.

Cui G, Ou Y, Chen Y, Lv D, Jia C, Zhong Z Front Psychiatry. 2020; 11:98.

PMID: 32194450 PMC: 7062961. DOI: 10.3389/fpsyt.2020.00098.

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Pagliaccio D, Cha J, He X, Cyr M, Yanes-Lukin P, Goldberg P J Child Psychol Psychiatry. 2020; 61(12):1299-1308.

PMID: 31889307 PMC: 7326644. DOI: 10.1111/jcpp.13191.

Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group.

Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A Am J Psychiatry. 2018; 175(5):453-462.

PMID: 29377733 PMC: 7106947. DOI: 10.1176/appi.ajp.2017.17050485.

Structural alterations in patients with obsessive-compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness.

Rus O, Reess T, Wagner G, Zaudig M, Zimmer C, Koch K J Psychiatry Neurosci. 2017; 42(6):395-403.

PMID: 28832321 PMC: 5662461. DOI: 10.1503/jpn.170030.

Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder.

Peng Z, Li G, Shi F, Shi C, Yang Q, Chan R Psychiatry Res. 2015; 234(3):346-51.

PMID: 26522981 PMC: 5546124. DOI: 10.1016/j.pscychresns.2015.10.005.

References

Pujol J, Soriano-Mas C, Alonso P, Cardoner N, Menchon J, Deus J . Mapping structural brain alterations in obsessive-compulsive disorder. Arch Gen Psychiatry. 2004; 61(7):720-30. DOI: 10.1001/archpsyc.61.7.720. View

Menzies L, Chamberlain S, Laird A, Thelen S, Sahakian B, Bullmore E . Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev. 2007; 32(3):525-49. PMC: 2889493. DOI: 10.1016/j.neubiorev.2007.09.005. View

Christian C, Lencz T, Robinson D, Burdick K, Ashtari M, Malhotra A . Gray matter structural alterations in obsessive-compulsive disorder: relationship to neuropsychological functions. Psychiatry Res. 2008; 164(2):123-31. PMC: 2654218. DOI: 10.1016/j.pscychresns.2008.03.005. View

Szeszko P, MacMillan S, McMeniman M, Lorch E, Madden R, Ivey J . Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings. Neuropsychopharmacology. 2004; 29(4):826-32. DOI: 10.1038/sj.npp.1300399. View

Aron A, Poldrack R . Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus. J Neurosci. 2006; 26(9):2424-33. PMC: 6793670. DOI: 10.1523/JNEUROSCI.4682-05.2006. View

Szeszko P, Robinson D, Alvir J, Bilder R, Lencz T, Ashtari M . Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Arch Gen Psychiatry. 1999; 56(10):913-9. DOI: 10.1001/archpsyc.56.10.913. View

Szeszko P, Christian C, MacMaster F, Lencz T, Mirza Y, Taormina S . Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study. Am J Psychiatry. 2008; 165(10):1299-307. DOI: 10.1176/appi.ajp.2008.08010033. View

Sowell E, Thompson P, Tessner K, Toga A . Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: Inverse relationships during postadolescent brain maturation. J Neurosci. 2001; 21(22):8819-29. PMC: 6762261. View

Grachev I, Breiter H, Rauch S, Savage C, Baer L, Shera D . Structural abnormalities of frontal neocortex in obsessive-compulsive disorder. Arch Gen Psychiatry. 1998; 55(2):181-2. DOI: 10.1001/archpsyc.55.2.181. View

10.

Valente Jr A, Miguel E, Castro C, Amaro Jr E, Duran F, Buchpiguel C . Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Biol Psychiatry. 2005; 58(6):479-87. DOI: 10.1016/j.biopsych.2005.04.021. View

11.

Insel T . Neurobiology of obsessive compulsive disorder: a review. Int Clin Psychopharmacol. 1992; 7 Suppl 1:31-3. DOI: 10.1097/00004850-199206001-00008. View

12.

Saxena S, Rauch S . Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am. 2000; 23(3):563-86. DOI: 10.1016/s0193-953x(05)70181-7. View

13.

Shin Y, Yoo S, Lee J, Ha T, Lee K, Lee J . Cortical thinning in obsessive compulsive disorder. Hum Brain Mapp. 2007; 28(11):1128-35. PMC: 6871365. DOI: 10.1002/hbm.20338. View

14.

Kim J, Lee M, Kim J, Kim I, Kim S, Han M . Grey matter abnormalities in obsessive-compulsive disorder: statistical parametric mapping of segmented magnetic resonance images. Br J Psychiatry. 2001; 179:330-4. DOI: 10.1192/bjp.179.4.330. View

15.

Szeszko P, MacMillan S, McMeniman M, Chen S, Baribault K, Lim K . Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder. Am J Psychiatry. 2004; 161(6):1049-56. DOI: 10.1176/appi.ajp.161.6.1049. View

16.

Roth R, Saykin A, Flashman L, Pixley H, West J, Mamourian A . Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder. Biol Psychiatry. 2007; 62(8):901-9. DOI: 10.1016/j.biopsych.2006.12.007. View

17.

Weissman M, Bland R, Canino G, Greenwald S, Hwu H, Lee C . The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. J Clin Psychiatry. 1994; 55 Suppl:5-10. View

18.

Saxena S, Brody A, Maidment K, Dunkin J, Colgan M, Alborzian S . Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology. 2000; 21(6):683-93. DOI: 10.1016/S0893-133X(99)00082-2. View

19.

Lippitz B, Mindus P, Meyerson B, Kihlstrom L, Lindquist C . Obsessive compulsive disorder and the right hemisphere: topographic analysis of lesions after anterior capsulotomy performed with thermocoagulation. Acta Neurochir Suppl. 1997; 68:61-3. DOI: 10.1007/978-3-7091-6513-3_11. View

20.

Saxena S, Brody A, Ho M, Alborzian S, Ho M, Maidment K . Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently. Biol Psychiatry. 2001; 50(3):159-70. DOI: 10.1016/s0006-3223(01)01123-4. View