Composition of Overlapping Protein-Protein and Protein-Ligand Interfaces

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Oct 31

PMID 26517868

Citations 6

Authors

Ruzianisra Mohamed

Jennifer Degac

Volkhard Helms

Affiliations

Soon will be listed here.

Abstract

Protein-protein interactions (PPIs) play a major role in many biological processes and they represent an important class of targets for therapeutic intervention. However, targeting PPIs is challenging because often no convenient natural substrates are available as starting point for small-molecule design. Here, we explored the characteristics of protein interfaces in five non-redundant datasets of 174 protein-protein (PP) complexes, and 161 protein-ligand (PL) complexes from the ABC database, 436 PP complexes, and 196 PL complexes from the PIBASE database and a dataset of 89 PL complexes from the Timbal database. In all cases, the small molecule ligands must bind at the respective PP interface. We observed similar amino acid frequencies in all three datasets. Remarkably, also the characteristics of PP contacts and overlapping PL contacts are highly similar.

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