The MiR-24-Bim Pathway Promotes Tumor Growth and Angiogenesis in Pancreatic Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2015 Oct 31

PMID 26517093

Citations 30

Authors

Rui Liu

Haiyang Zhang

Xia Wang

Likun Zhou

Hongli Li

Ting Deng

Yanjun Qu

Jingjing Duan

Ming Bai

Shaohua Ge

Tao Ning

Le Zhang

Dingzhi Huang

Yi Ba

Affiliations

Soon will be listed here.

Abstract

miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.

Citing Articles

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Huang J, Zhang Q, Ge Y, Zheng R, Yang M, Sun Y Sci Rep. 2025; 15(1):8159.

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Using microRNAs Networks to Understand Pancreatic Cancer-A Literature Review.

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Izdebska W, Daniluk J, Niklinski J J Clin Med. 2023; 12(17).

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