Angiogenesis-related Non-coding RNAs and Gastrointestinal Cancer

Overview

Journal Mol Ther Oncolytics

Publisher Cell Press

Date 2021 Jun 7

PMID 34095461

Citations 16

Authors

Zahra Sadat Razavi

Kasra Asgarpour

Maryam Mahjoubin-Tehran

Susan Rasouli

Haroon Khan

Mohammad Karim Shahrzad

Michael R Hamblin

Hamed Mirzaei

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers. Multiple lines of evidence have shown that angiogenesis has a key role in the growth and metastasis of all GI tumors. Abnormal angiogenesis also has a critical role in many non-malignant diseases. Therefore, angiogenesis is considered to be an important target for improved cancer treatment. Despite much research, the mechanisms governing angiogenesis are not completely understood. Recently, it has been shown that angiogenesis-related non-coding RNAs (ncRNAs) could affect the development of angiogenesis in cancer cells and tumors. The broad family of ncRNAs, which include long non-coding RNAs, microRNAs, and circular RNAs, are related to the development, promotion, and metastasis of GI cancers, especially in angiogenesis. This review discusses the role of ncRNAs in mediating angiogenesis in various types of GI cancers and looks forward to the introduction of mimetics and antagonists as possible therapeutic agents.

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References

Bang Y, Van Cutsem E, Feyereislova A, Chung H, Shen L, Sawaki A . Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010; 376(9742):687-97. DOI: 10.1016/S0140-6736(10)61121-X. View

Seiz L, Kotzsch M, Grebenchtchikov N, Geurts-Moespot A, Fuessel S, Goettig P . Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer. Biol Chem. 2010; 391(4):391-401. DOI: 10.1515/BC.2010.033. View

Macfarlane L, Murphy P . MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics. 2011; 11(7):537-61. PMC: 3048316. DOI: 10.2174/138920210793175895. View

Urbich C, Kaluza D, Fromel T, Knau A, Bennewitz K, Boon R . MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. Blood. 2011; 119(6):1607-16. DOI: 10.1182/blood-2011-08-373886. View

He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S . The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A. 2005; 102(52):19075-80. PMC: 1323209. DOI: 10.1073/pnas.0509603102. View

Watanabe Y, Shibata K, Kikkawa F, Kajiyama H, Ino K, Hattori A . Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system. Clin Cancer Res. 2003; 9(17):6497-503. View

Jonas K, Calin G, Pichler M . RNA-Binding Proteins as Important Regulators of Long Non-Coding RNAs in Cancer. Int J Mol Sci. 2020; 21(8). PMC: 7215867. DOI: 10.3390/ijms21082969. View

Muniyappa M, Dowling P, Henry M, Meleady P, Doolan P, Gammell P . MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. Eur J Cancer. 2009; 45(17):3104-18. DOI: 10.1016/j.ejca.2009.09.014. View

Cai C, Rodepeter F, Rossmann A, Teymoortash A, Lee J, Quint K . SIVmac₂₃₉-Nef down-regulates cell surface expression of CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis. Anticancer Res. 2012; 32(7):2759-68. View

10.

Zhang Y, Wang X, Xu B, Wang B, Wang Z, Liang Y . Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer. Oncol Rep. 2013; 30(4):1976-84. DOI: 10.3892/or.2013.2633. View

11.

George M, Tutton M, Abulafi A, Eccles S, Swift R . Plasma basic fibroblast growth factor levels in colorectal cancer: a clinically useful assay?. Clin Exp Metastasis. 2003; 19(8):735-8. DOI: 10.1023/a:1021322201816. View

12.

Ferre F, Colantoni A, Helmer-Citterich M . Revealing protein-lncRNA interaction. Brief Bioinform. 2015; 17(1):106-16. PMC: 4719072. DOI: 10.1093/bib/bbv031. View

13.

Thuringer D, Jego G, Berthenet K, Hammann A, Solary E, Garrido C . Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis. Oncotarget. 2016; 7(19):28160-8. PMC: 5053717. DOI: 10.18632/oncotarget.8583. View

14.

Kang S, Maeda K, Onoda N, Chung Y, Nakata B, Nishiguchi Y . Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. Int J Cancer. 1997; 74(5):502-7. DOI: 10.1002/(sici)1097-0215(19971021)74:5<502::aid-ijc4>3.0.co;2-7. View

15.

Ning B, Yu D, Yu A . Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics. Biochem Pharmacol. 2019; 169:113638. PMC: 6802278. DOI: 10.1016/j.bcp.2019.113638. View

16.

Ueki T, Koji T, Tamiya S, Nakane P, Tsuneyoshi M . Expression of basic fibroblast growth factor and fibroblast growth factor receptor in advanced gastric carcinoma. J Pathol. 1995; 177(4):353-61. DOI: 10.1002/path.1711770405. View

17.

Tang L, Wen J, Wen P, Li X, Gong M, Li Q . Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4. Cancer Cell Int. 2019; 19:94. PMC: 6458728. DOI: 10.1186/s12935-019-0799-9. View

18.

Wei L, Sun C, Zhang Y, Han N, Sun S . miR-503-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-A. Gene Ther. 2020; 29(1-2):28-40. DOI: 10.1038/s41434-020-0167-3. View

19.

Hangauer M, Vaughn I, McManus M . Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013; 9(6):e1003569. PMC: 3688513. DOI: 10.1371/journal.pgen.1003569. View

20.

Tang C, Xie Y, Yu T, Liu N, Wang Z, Woolsey R . mA-dependent biogenesis of circular RNAs in male germ cells. Cell Res. 2020; 30(3):211-228. PMC: 7054367. DOI: 10.1038/s41422-020-0279-8. View