Differential Ligand-signaling Network of CCL19/CCL21-CCR7 System

Overview

Journal Database (Oxford)

Specialty Biology

Date 2015 Oct 28

PMID 26504105

Citations 22

Authors

Rajesh Raju

Sachin Gadakh

Priyanka Gopal

Bijesh George

Jayshree Advani

Sowmya Soman

T S K Prasad

Reshmi Girijadevi

Affiliations

Soon will be listed here.

Abstract

Chemokine (C-C motif) receptor 7 (CCR7), a class A subtype G-Protein Coupled Receptor (GPCR), is involved in the migration, activation and survival of multiple cell types including dendritic cells, T cells, eosinophils, B cells, endothelial cells and different cancer cells. Together, CCR7 signaling system has been implicated in diverse biological processes such as lymph node homeostasis, T cell activation, immune tolerance, inflammatory response and cancer metastasis. CCL19 and CCL21, the two well-characterized CCR7 ligands, have been established to be differential in their signaling through CCR7 in multiple cell types. Although the differential ligand signaling through single receptor have been suggested for many receptors including GPCRs, there exists no resource or platform to analyse them globally. Here, first of its kind, we present the cell-type-specific differential signaling network of CCL19/CCL21-CCR7 system for effective visualization and differential analysis of chemokine/GPCR signaling. Database URL: http:// www. netpath. org/ pathways? path_ id= NetPath_ 46.

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