An Update on Transcriptional and Post-translational Regulation of Brain Voltage-gated Sodium Channels

Overview

Journal Amino Acids

Specialty Biochemistry

Date 2015 Oct 28

PMID 26503606

Citations 14

Authors

Donatus O Onwuli

Pedro Beltran-Alvarez

Affiliations

Soon will be listed here.

Abstract

Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (NaV1.1), SCN2A (NaV1.2), SCN3A (NaV1.3) and SCN8A (NaV1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.

Citing Articles

Voltage-Gated Ion Channels Are Transcriptional Targets of Sox10 during Oligodendrocyte Development.

Peters C, Aberle T, Sock E, Brunner J, Kuspert M, Hillgartner S Cells. 2024; 13(13.

PMID: 38995010 PMC: 11240802. DOI: 10.3390/cells13131159.

Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome.

Liebergall S, Goldberg E J Neurosci. 2024; 44(17).

PMID: 38443186 PMC: 11044195. DOI: 10.1523/JNEUROSCI.1977-23.2024.

Trifunctional Saxitoxin Conjugates for Covalent Labeling of Voltage-Gated Sodium Channels.

Finkelstein D, Du Bois J Chembiochem. 2023; 24(22):e202300493.

PMID: 37746898 PMC: 10863845. DOI: 10.1002/cbic.202300493.

Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

Marsden A, Riley D, Birkett S, Rodriguez-Barucg Q, Guinn B, Carroll S Amino Acids. 2021; 54(4):591-600.

PMID: 34181092 PMC: 9117359. DOI: 10.1007/s00726-021-03024-5.

Arginine methylation: the promise of a 'silver bullet' for brain tumours?.

Samuel S, Barry A, Greenman J, Beltran-Alvarez P Amino Acids. 2021; 53(4):489-506.

PMID: 33404912 PMC: 8107164. DOI: 10.1007/s00726-020-02937-x.

References

Khoury G, Baliban R, Floudas C . Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database. Sci Rep. 2011; 1. PMC: 3201773. DOI: 10.1038/srep00090. View

Few W, Scheuer T, Catterall W . Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15 and PKA by a modified leucine zipper motif. Proc Natl Acad Sci U S A. 2007; 104(12):5187-92. PMC: 1829284. DOI: 10.1073/pnas.0611619104. View

Mercier A, Clement R, Harnois T, Bourmeyster N, Bois P, Chatelier A . Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states. Biochim Biophys Acta. 2015; 1850(6):1215-23. DOI: 10.1016/j.bbagen.2015.02.009. View

Zhou J, Shin H, Yi J, Shen W, Williams C, Murray K . Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current. Circ Res. 2002; 91(6):540-6. DOI: 10.1161/01.res.0000033598.00903.27. View

Kim D, Gersbacher M, Inquimbert P, Kovacs D . Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem. 2010; 286(10):8106-8116. PMC: 3048697. DOI: 10.1074/jbc.M110.134692. View

Rougier J, van Bemmelen M, Bruce M, Jespersen T, Gavillet B, Apotheloz F . Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. Am J Physiol Cell Physiol. 2004; 288(3):C692-701. DOI: 10.1152/ajpcell.00460.2004. View

Lossin C . A catalog of SCN1A variants. Brain Dev. 2008; 31(2):114-30. DOI: 10.1016/j.braindev.2008.07.011. View

Bedford M, Clarke S . Protein arginine methylation in mammals: who, what, and why. Mol Cell. 2009; 33(1):1-13. PMC: 3372459. DOI: 10.1016/j.molcel.2008.12.013. View

Namadurai S, Yereddi N, Cusdin F, Huang C, Chirgadze D, Jackson A . A new look at sodium channel β subunits. Open Biol. 2015; 5(1):140192. PMC: 4313373. DOI: 10.1098/rsob.140192. View

10.

Iwata A, Stys P, Wolf J, Chen X, Taylor A, Meaney D . Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors. J Neurosci. 2004; 24(19):4605-13. PMC: 6729402. DOI: 10.1523/JNEUROSCI.0515-03.2004. View

11.

Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee K . Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2013; 13(1):372-87. PMC: 3879628. DOI: 10.1074/mcp.O113.027870. View

12.

Yu F, Catterall W . Overview of the voltage-gated sodium channel family. Genome Biol. 2003; 4(3):207. PMC: 153452. DOI: 10.1186/gb-2003-4-3-207. View

13.

Sarao R, Gupta S, Auld V, Dunn R . Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs. Nucleic Acids Res. 1991; 19(20):5673-9. PMC: 328974. DOI: 10.1093/nar/19.20.5673. View

14.

Martin M, Tang B, Ta N, Escayg A . Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences. Genomics. 2007; 90(2):225-35. PMC: 2637551. DOI: 10.1016/j.ygeno.2007.04.006. View

15.

Rogers L, Overall C . Proteolytic post-translational modification of proteins: proteomic tools and methodology. Mol Cell Proteomics. 2013; 12(12):3532-42. PMC: 3861706. DOI: 10.1074/mcp.M113.031310. View

16.

Buchner D, Trudeau M, Meisler M . SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science. 2003; 301(5635):967-9. DOI: 10.1126/science.1086187. View

17.

Laedermann C, Syam N, Pertin M, Decosterd I, Abriel H . β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells. Front Cell Neurosci. 2013; 7:137. PMC: 3757325. DOI: 10.3389/fncel.2013.00137. View

18.

Bosmans F, Milescu M, Swartz K . Palmitoylation influences the function and pharmacology of sodium channels. Proc Natl Acad Sci U S A. 2011; 108(50):20213-8. PMC: 3250191. DOI: 10.1073/pnas.1108497108. View

19.

Copley R . Evolutionary convergence of alternative splicing in ion channels. Trends Genet. 2004; 20(4):171-6. DOI: 10.1016/j.tig.2004.02.001. View

20.

Wong H, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H . beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem. 2005; 280(24):23009-17. DOI: 10.1074/jbc.M414648200. View