Genetic Associations of Periodic Limb Movements of Sleep in the Elderly for the MrOS Sleep Study

Overview

Journal Sleep Med

Specialties Neurology
Psychiatry

Date 2015 Oct 27

PMID 26498236

Citations 6

Authors

John W Winkelman

Terri Blackwell

Katie Stone

Sonia Ancoli-Israel

Gregory J Tranah

Susan Redline

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to assess the relationship between single-nucleotide polymorphisms associated with restless legs syndrome and periodic limb movements of sleep in a population cohort of elderly individuals.

Methods: Single-nucleotide polymorphisms previously associated with periodic limb movements of sleep or restless legs syndrome were analyzed in 2356 white male participants in the Osteoporotic Fractures in Men Sleep Study cohort. The associations between single-nucleotide polymorphisms and polysomnographically measured periodic limb movement index ≥15 were examined with logistic regression adjusted for age, ancestry markers, and periodic limb movements of sleep risk factors.

Results: Of the men in this cohort, 61% had a periodic limb movement index ≥15. Significant associations were observed between a periodic limb movement index ≥15 and the number of risk alleles for the two BTBD9 single-nucleotide polymorphisms (rs9357271[T], odds ratio [OR] = 1.38, 95% confidence interval [CI] 1.20-1.58; and rs3923809[A], OR = 1.43, 95% CI 1.26-1.63), one of the MEIS1 single-nucleotide polymorphisms (rs2300478[G], OR = 1.31, 95% CI 1.14-1.51) and the mitogen-activated protein kinase kinase 5 (MAP2K5)/Ski family transcriptional corepressor 1 (SKOR1) single-nucleotide polymorphism (rs1026732[G], OR = 1.16, 95% CI 1.02-1.31). In a multivariable model controlling for each of the two MEIS1 single-nucleotide polymorphisms, the rs6710341[A] single-nucleotide polymorphism became a significant risk allele (OR = 1.59, 95% CI 1.26-2.00).

Conclusions: Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 single-nucleotide polymorphisms and periodic limb movements of sleep in an elderly cohort not selected for the presence of restless legs syndrome.

Citing Articles

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The genetic etiology of periodic limb movement in sleep.

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Genetic risk for subjective reports of insomnia associates only weakly with polygraphic measures of insomnia in 2,770 adults.

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and Restless Legs Syndrome: A Comprehensive Review.

Sarayloo F, Dion P, Rouleau G Front Neurol. 2019; 10:935.

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