An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2015 Oct 23

PMID 26490462

Citations 29

Authors

Hossein Salehi

Noushin Amirpour

Ali Niapour

Shahnaz Razavi

Affiliations

Soon will be listed here.

Abstract

There is wide interest in application of adult stem cells due to easy to obtain with a minimal patient discomfort, capable of producing cell numbers in large quantities and their immunocompatible properties without restriction by ethical concerns. Among these stem cells, multipotent mesenchymal stem cells (MSCs) from human adipose tissue are considered as an ideal source for various regenerative medicine. In spite of mesodermal origin of human adipose-derived stem cells (hADSCs), these cells have differentiation potential toward mesodermal and non-mesodermal lineages. Up to now, several studies have shown that hADSCs can undergo transdifferentiation and produce cells outside of their lineage, especially into neural cells when they are transferred to a specific cell environment. The purpose of this literature review is to provide an overview of the existing state of knowledge of the differentiation potential of hADSCs, specifically their ability to give rise to neuronal cells. The following review discusses different protocols considered for differentiation of hADSCs to neural cells, the neural markers that are used in each procedure and possible mechanisms that are involved in this differentiation.

Citing Articles

Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells.

Chang M, Hong Y, Hsu C, Harn H, Huang B, Liu Y Stem Cells Transl Med. 2024; 13(3):293-308.

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The Neural Multilineage Differentiation Capacity of Human Neural Precursors from the Umbilical Cord-Ready to Bench for Clinical Trials.

de Souza Dobuchak D, Stricker P, Oliveira N, Mogharbel B, Rosa N, Dziedzic D Membranes (Basel). 2022; 12(9).

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Intravitreal Administration Effect of Adipose-Derived Mesenchymal Stromal Cells Combined with Anti-VEGF Nanocarriers, in a Pharmaceutically Induced Animal Model of Retinal Vein Occlusion.

Gounari E, Komnenou A, Kofidou E, Nanaki S, Bikiaris D, Almpanidou S Stem Cells Int. 2022; 2022:2760147.

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Impact of the Epigenetically Regulated Hoxa-5 Gene in Neural Differentiation from Human Adipose-Derived Stem Cells.

Hernandez R, Jimenez-Luna C, Ortiz R, Setien F, Lopez M, Perazzoli G Biology (Basel). 2021; 10(8).

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Nerve Suture Combined With ADSCs Injection Under Real-Time and Dynamic NIR-II Fluorescence Imaging in Peripheral Nerve Regeneration .

Dong S, Feng S, Chen Y, Chen M, Yang Y, Zhang J Front Chem. 2021; 9:676928.

PMID: 34336784 PMC: 8317167. DOI: 10.3389/fchem.2021.676928.

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