Relationship Between Intestinal Microbiota and Colorectal Cancer

Overview

Journal World J Gastrointest Oncol

Publisher Baishideng Publishing Group

Date 2015 Oct 21

PMID 26483877

Citations 22

Authors

Gokhan Cipe

Ufuk Oguz Idiz

Deniz Firat

Huseyin Bektasoglu

Affiliations

Soon will be listed here.

Abstract

The human gastrointestinal tract hosts a complex and vast microbial community with up to 10(11)-10(12) microorganisms colonizing the colon. The gut microbiota has a serious effect on homeostasis and pathogenesis through a number of mechanisms. In recent years, the relationship between the intestinal microbiota and sporadic colorectal cancer has attracted much scientific interest. Mechanisms underlying colonic carcinogenesis include the conversion of procarcinogenic diet-related factors to carcinogens and the stimulation of procarcinogenic signaling pathways in luminal epithelial cells. Understanding each of these mechanisms will facilitate future studies, leading to the development of novel strategies for the diagnosis, treatment, and prevention of colorectal cancer. In this review, we discuss the relationship between colorectal cancer and the intestinal microbiota.

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