Associations Between Anxiety and Depression Symptoms and Cognitive Testing and Neuroimaging in Type 2 Diabetes

Overview

Journal J Diabetes Complications

Specialty Endocrinology

Date 2015 Oct 19

PMID 26476474

Citations 11

Authors

Laura M Raffield

Gretchen A Brenes

Amanda J Cox

Barry I Freedman

Christina E Hugenschmidt

Fang-Chi Hsu

Jianzhao Xu

Benjamin C Wagner

Jeff D Williamson

Joseph A Maldjian

Donald W Bowden

Affiliations

Soon will be listed here.

Abstract

Aims: Anxiety, depression, accelerated cognitive decline, and increased risk of dementia are observed in individuals with type 2 diabetes. Anxiety and depression may contribute to lower performance on cognitive tests and differences in neuroimaging observed in individuals with type 2 diabetes.

Methods: These relationships were assessed in 655 European Americans with type 2 diabetes from 504 Diabetes Heart Study families. Participants completed cognitive testing, brain magnetic resonance imaging, the Brief Symptom Inventory Anxiety subscale, and the Center for Epidemiologic Studies Depression-10.

Results: In analyses adjusted for age, sex, educational attainment, and use of psychotropic medications, individuals with comorbid anxiety and depression symptoms had lower performance on all cognitive testing measures assessed (p≤0.005). Those with both anxiety and depression also had increased white matter lesion volume (p=0.015), decreased gray matter cerebral blood flow (p=4.43×10(-6)), decreased gray matter volume (p=0.002), increased white and gray matter mean diffusivity (p≤0.001), and decreased white matter fractional anisotropy (p=7.79×10(-4)). These associations were somewhat attenuated upon further adjustment for health status related covariates.

Conclusions: Comorbid anxiety and depression symptoms were associated with cognitive performance and brain structure in a European American cohort with type 2 diabetes.

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