Gold-Catalyzed Intramolecular Cyclization of N-Propargylic β-Enaminones for the Synthesis of 1,4-Oxazepine Derivatives

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2015 Oct 16

PMID 26468638

Citations 6

Authors

Kommuru Goutham

Desamala Ashok Kumar

Surisetti Suresh

Balasubramanian Sridhar

Ravirala Narender

Galla V Karunakar

Affiliations

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Abstract

An efficient and mild one-pot, gold-catalyzed intramolecular cyclization of N-propargylic β-enaminones has been achieved for the generation of 1,4-oxazepine derivatives. This synthetic transformation tolerates a range of substituted N-propargylic β-enaminones in moderate to good yields.

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