Structural Insights into Species-specific Features of the Ribosome from the Pathogen Staphylococcus Aureus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2015 Oct 15

PMID 26464510

Citations 64

Authors

Zohar Eyal

Donna Matzov

Miri Krupkin

Itai Wekselman

Susanne Paukner

Ella Zimmerman

Haim Rozenberg

Anat Bashan

Ada Yonath

Affiliations

Soon will be listed here.

Abstract

The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit from Staphylococcus aureus, a versatile Gram-positive aggressive pathogen, and its complexes with the known antibiotics linezolid and telithromycin, as well as with a new, highly potent pleuromutilin derivative, BC-3205. These crystal structures shed light on specific structural motifs of the S. aureus ribosome and the binding modes of the aforementioned antibiotics. Moreover, by analyzing the ribosome structure and comparing it with those of nonpathogenic bacterial models, we identified some unique internal and peripheral structural motifs that may be potential candidates for improving known antibiotics and for use in the design of selective antibiotic drugs against S. aureus.

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