Role of IGF-I Signaling in Muscle Bone Interactions

Overview

Journal Bone

Specialties Endocrinology
Orthopedics

Date 2015 Oct 11

PMID 26453498

Citations 65

Authors

Daniel D Bikle

Candice Tahimic

Wenhan Chang

Yongmei Wang

Anastassios Philippou

Elisabeth R Barton

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle and bone rely on a number of growth factors to undergo development, modulate growth, and maintain physiological strength. A major player in these actions is insulin-like growth factor I (IGF-I). However, because this growth factor can directly enhance muscle mass and bone density, it alters the state of the musculoskeletal system indirectly through mechanical crosstalk between these two organ systems. Thus, there are clearly synergistic actions of IGF-I that extend beyond the direct activity through its receptor. This review will cover the production and signaling of IGF-I as it pertains to muscle and bone, the chemical and mechanical influences that arise from IGF-I activity, and the potential for therapeutic strategies based on IGF-I. This article is part of a Special Issue entitled "Muscle Bone Interactions".

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