KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2015 Oct 9

PMID 26448950

Citations 36

Authors

Polin Haghvirdizadeh

Zahurin Mohamed

Nor Azizan Abdullah

Pantea Haghvirdizadeh

Monir Sadat Haerian

Batoul Sadat Haerian

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactions are involved in the insulin secretion pathway. Insulin secretion is mediated through the ATP-sensitive potassium (KATP) channel in pancreatic beta cells. This channel is a heteromeric protein, composed of four inward-rectifier potassium ion channel (Kir6.2) tetramers, which form the pore of the KATP channel, as well as sulfonylurea receptor 1 subunits surrounding the pore. Kir6.2 is encoded by the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) gene, a member of the potassium channel genes. Numerous studies have reported the involvement of single nucleotide polymorphisms of the KCNJ11 gene and their interactions in the susceptibility to DM. This review discusses the current evidence for the contribution of common KCNJ11 genetic variants to the development of DM. Future studies should concentrate on understanding the exact role played by these risk variants in the development of DM.

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