The Association of Serum Estradiol Level with Outcomes of Clomiphene Citrate/human Menopausal Gonadotropin Ovarian Stimulation for in Vitro Fertilization and Embryo Transfer

Overview

Journal Reprod Biol Endocrinol

Publisher Biomed Central

Specialties Endocrinology
Reproductive Medicine

Date 2015 Oct 8

PMID 26444856

Authors

Xiao-Jin Zhang

Su-Ying Liu

Wei Fu

Xiao-Xi Sun

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of this study was to test the hypothesis that estradiol (E2) level on day 3 may be associated with in vitro fertilization (IVF) outcomes.

Methods: The records of patients who received clomiphene citrate 100 mg/day plus human menopausal gonadotropin 150 IU/day from day 3 and received frozen-thawed embryo transfers were reviewed. Patients were divided into three groups: group A (E2 ≤30 pg/ml), group B (30< E2 ≤50 pg/ml), and group C (E2 >50 pg/ml). A total of 1080 cycles from 941 patients were included.

Results: The number of eggs and MII oocytes were less in group C than group A (both, P = 0.001). The embryo implantation (P = 0.006) and clinical pregnancy rates (P = 0.036) were lower in group C than group B, and the rates were similar between group A and B.

Conclusion: Maintaining the serum E2 level from 30 to 50 pg/ml may result in a higher clinical pregnancy rate in IVF cycles.

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