Impairment of Hematopoietic Stem Cell Niches in Patients with Aplastic Anemia

Overview

Journal Int J Hematol

Specialty Hematology

Date 2015 Oct 7

PMID 26440975

Citations 11

Authors

Liangliang Wu

Wenjian Mo

Yuping Zhang

Hui Deng

Yumiao Li

Ruiqing Zhou

Lu Zhang

Shiyi Pan

Shunqing Wang

Affiliations

Soon will be listed here.

Abstract

Aplastic anemia (AA) is a serious hematological disorder characterized by pancytopenia and defective bone marrow (BM) microenvironment. Previous investigations have demonstrated that there is a defect of angiogenesis in the BM of patients with AA. However, whether abnormalities of the BM microenvironment, particularly the overall specialization of niches, which have been classified into osteoblastic, vascular, and perivascular niches, are involved in the pathogenesis of AA is unknown. In the present study, 46 patients with AA and 15 controls were selected. The cellular elements of the BM microenvironment, including endosteal, vascular, and perivascular cells, were analyzed by immunohistochemical staining in situ. Patients with AA showed markedly fewer endosteal cells [0.33 vs 3.67 per high-power field (hpf); P < 0.05], vascular cells (8.00 vs 12.67 per hpf; P < 0.05), and perivascular cells (7.17 vs 10.67 per hpf; P < 0.05) compared with controls. These data indicate that AA is associated with impaired hematopoietic stem cell niches.

Citing Articles

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Jerkic M, Rabani R Int J Mol Sci. 2024; 25(2).

PMID: 38279269 PMC: 10816837. DOI: 10.3390/ijms25021269.

Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility.

Wang X, Li J, Wu K, Yang S, Chao Y Int J Mol Sci. 2023; 24(5).

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The Potential Association of Delayed T Lymphocyte Reconstitution Within Six Months Post-Transplantation With the Risk of Cytomegalovirus Retinitis in Severe Aplastic Anemia Recipients.

Mo W, Chen X, Zhang X, Wang S, Li L, Zhang Y Front Cell Infect Microbiol. 2022; 12:900154.

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VCAM-1+ macrophages usher hematopoietic stem and progenitor cell to vascular niche "hotspots".

Chiu Y, Aljitawi O Ann Transl Med. 2019; 7(Suppl 3):S116.

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Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment.

Medinger M, Drexler B, Lengerke C, Passweg J Front Oncol. 2018; 8:587.

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