What is the Definition of Cure for Aplastic Anemia?

Overview

Journal Acta Haematol

Specialty Hematology

Date 2000 Mar 8

PMID 10705154

Citations 25

Authors

B M Camitta

Affiliations

Soon will be listed here.

Abstract

Treatment with immune suppression and bone marrow transplantation has improved the response rates and survival of patients with aplastic anemia. Measurement of response requires that common endpoints be recorded at specific times. There has been no agreement on such parameters for patients with aplastic anemia. In this paper issues related to measurement of response are reviewed and criteria for response are proposed. Adoption of uniform criteria would facilitate comparisons of treatment efficacy.

Citing Articles

Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma.

Nakamura F, Nakamura Y, Nannya Y, Arai H, Shimbo K, Nakamura Y Leuk Res Rep. 2022; 17:100305.

PMID: 35371915 PMC: 8966168. DOI: 10.1016/j.lrr.2022.100305.

Significance of paroxysmal nocturnal hemoglobinuria clone in immunosuppressive therapy for children with severe aplastic anemia.

Li J, Zong S, Yin Z, Gao Y, Liu L, Wan Y Zhongguo Dang Dai Er Ke Za Zhi. 2022; 24(3):303-308.

PMID: 35351262 PMC: 8974654. DOI: 10.7499/j.issn.1008-8830.2110109.

Long-term outcomes of 172 children with severe aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine.

Lan Y, Chang L, Yi M, Cai Y, Feng J, Ren Y Ann Hematol. 2020; 100(1):53-61.

PMID: 33033910 DOI: 10.1007/s00277-020-04296-9.

Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.

Elbadry M, Mizumaki H, Hosokawa K, Espinoza J, Nakagawa N, Chonabayashi K Haematologica. 2019; 104(10):e447-e450.

PMID: 30890597 PMC: 6886421. DOI: 10.3324/haematol.2018.210856.

Immunosuppressive therapy with rabbit antithymocyte globulin therapy for acquired aplastic anemia: a multi-institutional retrospective study in Japanese adult patients.

Sasaki N, Shimura K, Yoshida M, Uoshima N, Kiyota M, Hatsuse M Int J Hematol. 2019; 109(3):278-285.

PMID: 30627868 DOI: 10.1007/s12185-018-02583-w.