Biomaterial Strategies for Immunomodulation

Overview

Journal Annu Rev Biomed Eng

Publisher Annual Reviews

Specialty Biomedical Engineering

Date 2015 Oct 1

PMID 26421896

Citations 66

Authors

Nathan A Hotaling

Li Tang

Darrell J Irvine

Julia E Babensee

Affiliations

Soon will be listed here.

Abstract

Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medicine, and immunotherapies for cancer. However, the intricate cellular and molecular signals regulating the immune system are major hurdles to predictably manipulating the immune response and developing safe and effective therapies. To meet this challenge, biomaterials are being developed that control how, where, and when immune cells are stimulated in vivo, and that can finely control their differentiation in vitro. We review recent advances in the field of biomaterials for immunomodulation, focusing particularly on designing biomaterials to provide controlled immunostimulation, targeting drugs and vaccines to lymphoid organs, and serving as scaffolds to organize immune cells and emulate lymphoid tissues. These ongoing efforts highlight the many ways in which biomaterials can be brought to bear to engineer the immune system.

Citing Articles

Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings.

Mishra S, Akter T, Urmi U, Enninful G, Sara M, Shen J Antibiotics (Basel). 2025; 14(1).

PMID: 39858343 PMC: 11762091. DOI: 10.3390/antibiotics14010057.

Status of islet transplantation and innovations to sustainable outcomes: novel sites, cell sources, and drug delivery strategies.

Wong J, Pepper A Front Transplant. 2024; 3:1485444.

PMID: 39553396 PMC: 11565603. DOI: 10.3389/frtra.2024.1485444.

Characterization of a decellularized pericardium extracellular matrix hydrogel for regenerative medicine: insights on animal-to-animal variability.

Di Francesco D, Marcello E, Casarella S, Copes F, Chevallier P, Carmagnola I Front Bioeng Biotechnol. 2024; 12:1452965.

PMID: 39205858 PMC: 11350490. DOI: 10.3389/fbioe.2024.1452965.

Navigating the Immunological Crossroads: Mesenchymal Stem/Stromal Cells as Architects of Inflammatory Harmony in Tissue-Engineered Constructs.

Farzamfar S, Melo Garcia L, Rahmani M, Bolduc S Bioengineering (Basel). 2024; 11(5).

PMID: 38790361 PMC: 11118848. DOI: 10.3390/bioengineering11050494.

Advances and challenges of the cell-based therapies among diabetic patients.

Raoufinia R, Rahimi H, Saburi E, Moghbeli M J Transl Med. 2024; 22(1):435.

PMID: 38720379 PMC: 11077715. DOI: 10.1186/s12967-024-05226-3.

References

Golumbek P, Azhari R, Jaffee E, Levitsky H, Lazenby A, Leong K . Controlled release, biodegradable cytokine depots: a new approach in cancer vaccine design. Cancer Res. 1993; 53(24):5841-4. View

Anderson A, Shaw S . Conduit for privileged communications in the lymph node. Immunity. 2005; 22(1):3-5. DOI: 10.1016/j.immuni.2005.01.003. View

Giese C, Lubitz A, Demmler C, Reuschel J, Bergner K, Marx U . Immunological substance testing on human lymphatic micro-organoids in vitro. J Biotechnol. 2010; 148(1):38-45. DOI: 10.1016/j.jbiotec.2010.03.001. View

Baumgartner H . The role of blood flow in platelet adhesion, fibrin deposition, and formation of mural thrombi. Microvasc Res. 1973; 5(2):167-79. DOI: 10.1016/0026-2862(73)90069-1. View

Decuzzi P, Pasqualini R, Arap W, Ferrari M . Intravascular delivery of particulate systems: does geometry really matter?. Pharm Res. 2008; 26(1):235-43. DOI: 10.1007/s11095-008-9697-x. View

Demento S, Steenblock E, Fahmy T . Biomimetic approaches to modulating the T cell immune response with nano- and micro- particles. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:1161-6. DOI: 10.1109/IEMBS.2009.5332625. View

He C, Hu Y, Yin L, Tang C, Yin C . Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials. 2010; 31(13):3657-66. DOI: 10.1016/j.biomaterials.2010.01.065. View

Champion J, Mitragotri S . Shape induced inhibition of phagocytosis of polymer particles. Pharm Res. 2008; 26(1):244-9. PMC: 2810499. DOI: 10.1007/s11095-008-9626-z. View

Puffer E, Pontrello J, Hollenbeck J, Kink J, Kiessling L . Activating B cell signaling with defined multivalent ligands. ACS Chem Biol. 2007; 2(4):252-62. DOI: 10.1021/cb600489g. View

10.

Aldinucci A, Turco A, Biagioli T, Toma F, Bani D, Guasti D . Carbon nanotube scaffolds instruct human dendritic cells: modulating immune responses by contacts at the nanoscale. Nano Lett. 2013; 13(12):6098-105. DOI: 10.1021/nl403396e. View

11.

Shultz L, Brehm M, Garcia-Martinez J, Greiner D . Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol. 2012; 12(11):786-98. PMC: 3749872. DOI: 10.1038/nri3311. View

12.

Nakaya H, Wrammert J, Lee E, Racioppi L, Marie-Kunze S, Nicholas Haining W . Systems biology of vaccination for seasonal influenza in humans. Nat Immunol. 2011; 12(8):786-95. PMC: 3140559. DOI: 10.1038/ni.2067. View

13.

Shokouhi B, Coban C, Hasirci V, Aydin E, Dhanasingh A, Shi N . The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells. Biomaterials. 2010; 31(22):5759-71. DOI: 10.1016/j.biomaterials.2010.04.015. View

14.

Thomas T, Goonewardena S, Majoros I, Kotlyar A, Cao Z, Leroueil P . Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis. Arthritis Rheum. 2011; 63(9):2671-80. PMC: 3168725. DOI: 10.1002/art.30459. View

15.

Hornung V, Bauernfeind F, Halle A, Samstad E, Kono H, Rock K . Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008; 9(8):847-56. PMC: 2834784. DOI: 10.1038/ni.1631. View

16.

Freedman M, Bar-Or A, Oger J, Traboulsee A, Patry D, Young C . A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS. Neurology. 2011; 77(16):1551-60. DOI: 10.1212/WNL.0b013e318233b240. View

17.

Dudley M, Wunderlich J, Robbins P, Yang J, Hwu P, Schwartzentruber D . Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002; 298(5594):850-4. PMC: 1764179. DOI: 10.1126/science.1076514. View

18.

Tan J, Watanabe T . Artificial engineering of secondary lymphoid organs. Adv Immunol. 2010; 105:131-57. DOI: 10.1016/S0065-2776(10)05005-4. View

19.

Xiao K, Li Y, Luo J, Lee J, Xiao W, Gonik A . The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials. 2011; 32(13):3435-46. PMC: 3055170. DOI: 10.1016/j.biomaterials.2011.01.021. View

20.

Yoo J, Doshi N, Mitragotri S . Endocytosis and Intracellular Distribution of PLGA Particles in Endothelial Cells: Effect of Particle Geometry. Macromol Rapid Commun. 2011; 31(2):142-8. DOI: 10.1002/marc.200900592. View