HIV: Antiviral Action Countered by Nef

Overview

Journal Nature

Specialty Science

Date 2015 Sep 30

PMID 26416750

Citations 6

Authors

Christopher Aiken

Affiliations

Soon will be listed here.

Citing Articles

SERINC5 counters retroviruses and non-retroviruses.

Yu J, Liu C, Qu X, Gao X, Liu Y Front Cell Infect Microbiol. 2025; 14:1516806.

PMID: 39902183 PMC: 11788155. DOI: 10.3389/fcimb.2024.1516806.

SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways.

Zeng C, Waheed A, Li T, Yu J, Zheng Y, Yount J Sci Signal. 2021; 14(700):eabc7611.

PMID: 34520227 PMC: 9549701. DOI: 10.1126/scisignal.abc7611.

Mechanical characterization of vesicles and cells: A review.

Morshed A, Karawdeniya B, Bandara Y, Kim M, Dutta P Electrophoresis. 2020; 41(7-8):449-470.

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TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins.

Li M, Waheed A, Yu J, Zeng C, Chen H, Zheng Y Proc Natl Acad Sci U S A. 2019; 116(12):5705-5714.

PMID: 30842281 PMC: 6431140. DOI: 10.1073/pnas.1819475116.

Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes.

Uhl J, Gujarathi S, Waheed A, Gordon A, Freed E, Gousset K J Cell Commun Signal. 2018; 13(2):209-224.

PMID: 30443895 PMC: 6498342. DOI: 10.1007/s12079-018-0493-z.

References

Aiken C . Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. J Virol. 1997; 71(8):5871-7. PMC: 191842. DOI: 10.1128/JVI.71.8.5871-5877.1997. View

Usami Y, Wu Y, Gottlinger H . SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. Nature. 2015; 526(7572):218-23. PMC: 4600458. DOI: 10.1038/nature15400. View

Pizzato M . MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1. Proc Natl Acad Sci U S A. 2010; 107(20):9364-9. PMC: 2889076. DOI: 10.1073/pnas.1001554107. View

Inuzuka M, Hayakawa M, Ingi T . Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. J Biol Chem. 2005; 280(42):35776-83. DOI: 10.1074/jbc.M505712200. View

Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh S . HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature. 2015; 526(7572):212-7. PMC: 4861059. DOI: 10.1038/nature15399. View

Day J, Munk C, Guatelli J . The membrane-proximal tyrosine-based sorting signal of human immunodeficiency virus type 1 gp41 is required for optimal viral infectivity. J Virol. 2004; 78(3):1069-79. PMC: 321364. DOI: 10.1128/jvi.78.3.1069-1079.2004. View

Qi M, Aiken C . Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. J Virol. 2006; 81(3):1534-6. PMC: 1797497. DOI: 10.1128/JVI.02099-06. View

Usami Y, Gottlinger H . HIV-1 Nef responsiveness is determined by Env variable regions involved in trimer association and correlates with neutralization sensitivity. Cell Rep. 2013; 5(3):802-12. PMC: 3864691. DOI: 10.1016/j.celrep.2013.09.028. View

Pizzato M, Helander A, Popova E, Calistri A, Zamborlini A, Palu G . Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci U S A. 2007; 104(16):6812-7. PMC: 1871867. DOI: 10.1073/pnas.0607622104. View

10.

Zhou J, Aiken C . Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope. J Virol. 2001; 75(13):5851-9. PMC: 114300. DOI: 10.1128/JVI.75.13.5851-5859.2001. View

11.

Chazal N, Singer G, Aiken C, Hammarskjold M, Rekosh D . Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity. J Virol. 2001; 75(8):4014-8. PMC: 114896. DOI: 10.1128/JVI.75.8.4014-4018.2001. View