» Articles » PMID: 26413485

Endoscopic Management of Adenomatous Ampullary Lesions

Overview
Specialty General Medicine
Date 2015 Sep 29
PMID 26413485
Citations 5
Authors
Affiliations
Soon will be listed here.
Abstract

Lesions of the ampulla of Vater represent an uncommon group of gastrointestinal malignancies. The majority of lesions of the ampulla of Vater are either adenomas or adenocarcinomas. Ampullary lesions are often incidental findings. Accurate preoperative diagnosis and staging of ampullary tumors is imperative for predicting prognosis and determining the most appropriate therapeutic approach. Endoscopic ampullectomy is a safe and efficacious therapeutic procedure that can obviate the need for potentially major surgical intervention. This review will provide the framework for the diagnosis and management of ampullary lesions from the perspective of the practicing gastroenterologist. Strategies for safe and successful endoscopic ampullectomy with a focus on accurate preoperative diagnosis and staging, resection technique, and management of complications are presented.

Citing Articles

Factors associated with delayed bleeding following ampullectomy: A retrospective cohort study.

Pawlak K, Khalaf K, Gupta S, Tham D, Chon J, Mokhtar A DEN Open. 2025; 5(1):e70078.

PMID: 39959850 PMC: 11827579. DOI: 10.1002/deo2.70078.


A Case of Pedunculated Adenoma of the Bile Duct Proving Adenoma to Cancer Sequence.

Ahsan M, Jarbath M, Davis B, Provance W Cureus. 2024; 16(4):e58304.

PMID: 38752036 PMC: 11095132. DOI: 10.7759/cureus.58304.


Microscopic transduodenal excision of an ampullary adenoma: A case report and review of the literature.

Zheng X, Sun Q, Zhou B, Jin M, Yan S World J Clin Cases. 2021; 9(18):4844-4851.

PMID: 34222457 PMC: 8223850. DOI: 10.12998/wjcc.v9.i18.4844.


Systematic Review with Meta-Analysis: Endoscopic and Surgical Resection for Ampullary Lesions.

Heise C, Ali E, Hasenclever D, Auriemma F, Gulla A, Regner S J Clin Med. 2020; 9(11).

PMID: 33182806 PMC: 7696506. DOI: 10.3390/jcm9113622.


Study Protocol of the ESAP Study: Endoscopic Papillectomy vs. Surgical Ampullectomy vs. Pancreaticoduodenectomy for Ampullary Neoplasm-A Pancreas2000/EPC Study.

Hollenbach M, Ali E, Auriemma F, Gulla A, Heise C, Regner S Front Med (Lausanne). 2020; 7:152.

PMID: 32435644 PMC: 7218136. DOI: 10.3389/fmed.2020.00152.


References
1.
Rattner D, Fernandez-Del Castillo C, Brugge W, Warshaw A . Defining the criteria for local resection of ampullary neoplasms. Arch Surg. 1996; 131(4):366-71. DOI: 10.1001/archsurg.1996.01430160024003. View

2.
Martin J, Haber G . Ampullary adenoma: clinical manifestations, diagnosis, and treatment. Gastrointest Endosc Clin N Am. 2004; 13(4):649-69. DOI: 10.1016/s1052-5157(03)00101-6. View

3.
de Castro S, van Heek N, Kuhlmann K, Busch O, Offerhaus G, van Gulik T . Surgical management of neoplasms of the ampulla of Vater: local resection or pancreatoduodenectomy and prognostic factors for survival. Surgery. 2004; 136(5):994-1002. DOI: 10.1016/j.surg.2004.03.010. View

4.
Ceppa E, Burbridge R, Rialon K, Omotosho P, Emick D, Jowell P . Endoscopic versus surgical ampullectomy: an algorithm to treat disease of the ampulla of Vater. Ann Surg. 2012; 257(2):315-22. DOI: 10.1097/SLA.0b013e318269d010. View

5.
Hopper A, Bourke M, Williams S, Swan M . Giant laterally spreading tumors of the papilla: endoscopic features, resection technique, and outcome (with videos). Gastrointest Endosc. 2010; 71(6):967-75. DOI: 10.1016/j.gie.2009.11.021. View