Empowering Gamma Delta T Cells with Antitumor Immunity by Dendritic Cell-based Immunotherapy

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2015 Sep 26

PMID 26405575

Citations 39

Authors

Heleen H Van Acker

Sebastien Anguille

Viggo F Van Tendeloo

Eva Lion

Affiliations

Soon will be listed here.

Abstract

Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8 and CD4 T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the γδ T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated γδ T cell activation and related opportunities for tumor immunologists.

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