Human Gamma Delta T Cells: Candidates for the Development of Immunotherapeutic Strategies

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2007 Aug 19

PMID 17695246

Citations 23

Authors

Susann Beetz

Lothar Marischen

Dieter Kabelitz

Daniela Wesch

Affiliations

Soon will be listed here.

Abstract

A numerically small subset of human T lymphocytes expresses a gamma delta T cell receptor (TCR). These gamma delta T cells share certain effector functions with alpha beta T cells as well as with NK cells and NKT cells. The major peripheral blood gamma delta T cell subset in healthy adults expresses a Vgamma9Vdelta2 TCR, which recognizes small phosphorylated metabolites referred to as phosphoantigens. Vdelta1 gamma delta T cells mainly occur in the intestine. They recognize the stress-induced MICA/B and CD1c. Furthermore, gamma delta T cells express a variety of NK cell and pattern-recognition receptors which are responsible for the "fine-tuning" of effector functions. In recent years, gamma delta T cells start to emerge as a rewarding target for immunotherapeutic strategies against viral infections and cancer. A better understanding of factors that modulate gamma gamma delta T cell function will further eluminate the potential of these cells.

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