A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle As a Smart Theranostic Agent with Ultrahigh PH-Responsive Longitudinal Relaxivity

Overview

Journal Adv Mater

Date 2015 Sep 23

PMID 26393889

Citations 50

Authors

Xiaojun Cai

Wei Gao

Ming Ma

Meiying Wu

Linlin Zhang

Yuanyi Zheng

Hangrong Chen

Jianlin Shi

Affiliations

Soon will be listed here.

Abstract

Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1 -weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m(-1) s(-1) ), and achieves the real-time monitoring of drug release.

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