MOFs and MOF-Derived Materials for Antibacterial Application

Overview

Journal J Funct Biomater

Specialty Biomedical Engineering

Date 2022 Nov 22

PMID 36412856

Authors

Xin Zhang

Feng Peng

Donghui Wang

Affiliations

Soon will be listed here.

Abstract

Bacterial infections pose a serious threat to people's health. Efforts are being made to develop antibacterial agents that can inhibit bacterial growth, prevent biofilm formation, and kill bacteria. In recent years, materials based on metal organic frameworks (MOFs) have attracted significant attention for various antibacterial applications due to their high specific surface area, high enzyme-like activity, and continuous release of metal ions. This paper reviews the recent progress of MOFs as antibacterial agents, focusing on preparation methods, fundamental antibacterial mechanisms, and strategies to enhance their antibacterial effects. Finally, several prospects related to MOFs for antibacterial application are proposed, aiming to provide possible research directions in this field.

Citing Articles

Development of a Magnetic Solid-Phase Extraction-Liquid Chromatography Targeted to Five Fluoroquinolones in Food Based on Aptamer Recognition.

Zhou H, Yan X, Song Y, Yang X, Chen X, Huang Y Foods. 2025; 14(5).

PMID: 40077500 PMC: 11899132. DOI: 10.3390/foods14050798.

Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings.

Wang M, Luo Y, Yang Q, Chen J, Feng M, Tang Y Int J Nanomedicine. 2025; 20:2813-2846.

PMID: 40066324 PMC: 11892508. DOI: 10.2147/IJN.S508036.

Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review.

Damian-Buda A, Alipanah N, Bider F, Sisman O, Nescakova Z, Boccaccini A Mater Today Bio. 2025; 30():101413.

PMID: 39834480 PMC: 11742841. DOI: 10.1016/j.mtbio.2024.101413.

Bactericidal Metal-Organic Gallium Frameworks - Synthesis to Application.

Cordeiro Gomes F, Ferreira Alves M, Junior S, Medina S Mol Pharm. 2024; 22(2):638-646.

PMID: 39729416 PMC: 11795525. DOI: 10.1021/acs.molpharmaceut.4c01253.

Gamma-irradiated copper-based metal organic framework nanocomposites for photocatalytic degradation of water pollutants and disinfection of some pathogenic bacteria and fungi.

El-Sayyad G, El-Khawaga A, Rashdan H BMC Microbiol. 2024; 24(1):453.

PMID: 39506685 PMC: 11539452. DOI: 10.1186/s12866-024-03587-9.

References

Wang Q, Ina T, Chen W, Shang L, Sun F, Wei S . Evolution of Zn(II) single atom catalyst sites during the pyrolysis-induced transformation of ZIF-8 to N-doped carbons. Sci Bull (Beijing). 2023; 65(20):1743-1751. DOI: 10.1016/j.scib.2020.06.020. View

Hatamie S, Ahadian M, Soufi Zomorod M, Torabi S, Babaie A, Hosseinzadeh S . Antibacterial properties of nanoporous graphene oxide/cobalt metal organic framework. Mater Sci Eng C Mater Biol Appl. 2019; 104:109862. DOI: 10.1016/j.msec.2019.109862. View

Liu J, Liu T, Du P, Zhang L, Lei J . Metal-Organic Framework (MOF) Hybrid as a Tandem Catalyst for Enhanced Therapy against Hypoxic Tumor Cells. Angew Chem Int Ed Engl. 2019; 58(23):7808-7812. DOI: 10.1002/anie.201903475. View

Kovalakova P, Cizmas L, McDonald T, Marsalek B, Feng M, Sharma V . Occurrence and toxicity of antibiotics in the aquatic environment: A review. Chemosphere. 2020; 251:126351. DOI: 10.1016/j.chemosphere.2020.126351. View

Zheng H, Liu C, Zeng X, Chen J, Lu J, Lin R . MOF-808: A Metal-Organic Framework with Intrinsic Peroxidase-Like Catalytic Activity at Neutral pH for Colorimetric Biosensing. Inorg Chem. 2018; 57(15):9096-9104. DOI: 10.1021/acs.inorgchem.8b01097. View

Zheng Q, Liu X, Zheng Y, Yeung K, Cui Z, Liang Y . The recent progress on metal-organic frameworks for phototherapy. Chem Soc Rev. 2021; 50(8):5086-5125. DOI: 10.1039/d1cs00056j. View

Travlou N, Algarra M, Alcoholado C, Cifuentes-Rueda M, Labella A, Lazaro-Martinez J . Carbon Quantum Dot Surface-Chemistry-Dependent Ag Release Governs the High Antibacterial Activity of Ag-Metal-Organic Framework Composites. ACS Appl Bio Mater. 2022; 1(3):693-707. DOI: 10.1021/acsabm.8b00166. View

Banerjee R, Phan A, Wang B, Knobler C, Furukawa H, OKeeffe M . High-throughput synthesis of zeolitic imidazolate frameworks and application to CO2 capture. Science. 2008; 319(5865):939-43. DOI: 10.1126/science.1152516. View

Pan X, Wang W, Huang Z, Liu S, Guo J, Zhang F . MOF-Derived Double-Layer Hollow Nanoparticles with Oxygen Generation Ability for Multimodal Imaging-Guided Sonodynamic Therapy. Angew Chem Int Ed Engl. 2020; 59(32):13557-13561. DOI: 10.1002/anie.202004894. View

10.

Yamanaka M, Hara K, Kudo J . Bactericidal actions of a silver ion solution on Escherichia coli, studied by energy-filtering transmission electron microscopy and proteomic analysis. Appl Environ Microbiol. 2005; 71(11):7589-93. PMC: 1287701. DOI: 10.1128/AEM.71.11.7589-7593.2005. View

11.

Fu Q, Saltsburg H, Flytzani-Stephanopoulos M . Active nonmetallic Au and Pt species on ceria-based water-gas shift catalysts. Science. 2003; 301(5635):935-8. DOI: 10.1126/science.1085721. View

12.

Ma S, Sun D, Simmons J, Collier C, Yuan D, Zhou H . Metal-organic framework from an anthracene derivative containing nanoscopic cages exhibiting high methane uptake. J Am Chem Soc. 2008; 130(3):1012-6. DOI: 10.1021/ja0771639. View

13.

Cun J, Fan X, Pan Q, Gao W, Luo K, He B . Copper-based metal-organic frameworks for biomedical applications. Adv Colloid Interface Sci. 2022; 305:102686. DOI: 10.1016/j.cis.2022.102686. View

14.

Akbarzadeh F, Motaghi M, Chauhan N, Sargazi G . A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application. Heliyon. 2020; 6(1):e03231. PMC: 6994313. DOI: 10.1016/j.heliyon.2020.e03231. View

15.

Chen M, Zhang J, Qi J, Dong R, Liu H, Wu D . Boronic Acid-Decorated Multivariate Photosensitive Metal-Organic Frameworks for Combating Multi-Drug-Resistant Bacteria. ACS Nano. 2022; 16(5):7732-7744. DOI: 10.1021/acsnano.1c11613. View

16.

Yu Z, Hu W, Zhao H, Miao X, Guan Y, Cai W . Generating New Cross-Relaxation Pathways by Coating Prussian Blue on NaNdF To Fabricate Enhanced Photothermal Agents. Angew Chem Int Ed Engl. 2019; 58(25):8536-8540. DOI: 10.1002/anie.201904534. View

17.

Hou H, Huang X, Wei G, Xu F, Wang Y, Zhou S . Fenton Reaction-Assisted Photodynamic Therapy for Cancer with Multifunctional Magnetic Nanoparticles. ACS Appl Mater Interfaces. 2019; 11(33):29579-29592. DOI: 10.1021/acsami.9b09671. View

18.

Yang B, Chen Y, Shi J . Reactive Oxygen Species (ROS)-Based Nanomedicine. Chem Rev. 2019; 119(8):4881-4985. DOI: 10.1021/acs.chemrev.8b00626. View

19.

Granato E, Meiller-Legrand T, Foster K . The Evolution and Ecology of Bacterial Warfare. Curr Biol. 2019; 29(11):R521-R537. DOI: 10.1016/j.cub.2019.04.024. View

20.

Sirelkhatim A, Mahmud S, Seeni A, Kaus N, Ann L, Mohd Bakhori S . Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism. Nanomicro Lett. 2018; 7(3):219-242. PMC: 6223899. DOI: 10.1007/s40820-015-0040-x. View