The B-cell Antigen Receptor Integrates Adaptive and Innate Immune Signals

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2015 Sep 16

PMID 26371314

Citations 24

Authors

Kevin L Otipoby

Ari Waisman

Emmanuel Derudder

Lakshmi Srinivasan

Andrew Franklin

Klaus Rajewsky

Affiliations

Soon will be listed here.

Abstract

B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.

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