WASP: Allele-specific Software for Robust Molecular Quantitative Trait Locus Discovery

Overview

Journal Nat Methods

Specialties Biomedical Engineering
Pathology

Date 2015 Sep 15

PMID 26366987

Citations 294

Authors

Bryce van de Geijn

Graham McVicker

Yoav Gilad

Jonathan K Pritchard

Affiliations

Soon will be listed here.

Abstract

Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical artifacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and chromatin immunoprecipitation sequencing (ChIP-seq) reads, we demonstrate that WASP has a low error rate and is far more powerful than existing QTL-mapping approaches.

Citing Articles

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