The Microbiome Modulates Arbovirus Transmission in Mosquitoes

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2015 Sep 14

PMID 26363996

Citations 110

Authors

Shivanand Hegde

Jason L Rasgon

Grant L Hughes

Affiliations

Soon will be listed here.

Abstract

Mosquito-transmitted arthropod-borne viruses (arboviruses) such as dengue virus, chikungunya virus, and West Nile virus constitute a major public health burden and are increasing in severity and frequency worldwide. The microbiota associated with mosquitoes (comprised of viruses, bacteria, fungi and protozoa) can profoundly influence many host phenotypes including vector competence, which can either be enhanced or suppressed. Thus, the tripartite interactions between the mosquito vector, its microbiota and the pathogens they transmit offer novel possibilities to control arthropod-borne diseases.

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References

Dong Y, Morton Jr J, Ramirez J, Souza-Neto J, Dimopoulos G . The entomopathogenic fungus Beauveria bassiana activate toll and JAK-STAT pathway-controlled effector genes and anti-dengue activity in Aedes aegypti. Insect Biochem Mol Biol. 2011; 42(2):126-32. PMC: 3462650. DOI: 10.1016/j.ibmb.2011.11.005. View

Dheilly N . Holobiont-Holobiont interactions: redefining host-parasite interactions. PLoS Pathog. 2014; 10(7):e1004093. PMC: 4081813. DOI: 10.1371/journal.ppat.1004093. View

Minard G, Tran F, Dubost A, Tran-Van V, Mavingui P, Valiente Moro C . Pyrosequencing 16S rRNA genes of bacteria associated with wild tiger mosquito Aedes albopictus: a pilot study. Front Cell Infect Microbiol. 2014; 4:59. PMC: 4030203. DOI: 10.3389/fcimb.2014.00059. View

Perera R, Riley C, Isaac G, Hopf-Jannasch A, Moore R, Weitz K . Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathog. 2012; 8(3):e1002584. PMC: 3310792. DOI: 10.1371/journal.ppat.1002584. View

Whyard S, Erdelyan C, Partridge A, Singh A, Beebe N, Capina R . Silencing the buzz: a new approach to population suppression of mosquitoes by feeding larvae double-stranded RNAs. Parasit Vectors. 2015; 8:96. PMC: 4331333. DOI: 10.1186/s13071-015-0716-6. View

Dennison N, Jupatanakul N, Dimopoulos G . The mosquito microbiota influences vector competence for human pathogens. Curr Opin Insect Sci. 2015; 3:6-13. PMC: 4288011. DOI: 10.1016/j.cois.2014.07.004. View

Xi Z, Ramirez J, Dimopoulos G . The Aedes aegypti toll pathway controls dengue virus infection. PLoS Pathog. 2008; 4(7):e1000098. PMC: 2435278. DOI: 10.1371/journal.ppat.1000098. View

Hughes G, Pike A, Xue P, Rasgon J . Invasion of Wolbachia into Anopheles and other insect germlines in an ex vivo organ culture system. PLoS One. 2012; 7(4):e36277. PMC: 3340357. DOI: 10.1371/journal.pone.0036277. View

McFarlane M, Arias-Goeta C, Martin E, OHara Z, Lulla A, Mousson L . Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Negl Trop Dis. 2014; 8(7):e2994. PMC: 4109886. DOI: 10.1371/journal.pntd.0002994. View

10.

Joyce J, Nogueira J, Bales A, Pittman K, Anderson J . Interactions between La Crosse virus and bacteria isolated from the digestive tract of Aedes albopictus (Diptera: Culicidae). J Med Entomol. 2011; 48(2):389-94. DOI: 10.1603/me09268. View

11.

Hill C, Sharma A, Shouche Y, Severson D . Dynamics of midgut microflora and dengue virus impact on life history traits in Aedes aegypti. Acta Trop. 2014; 140:151-7. PMC: 4253069. DOI: 10.1016/j.actatropica.2014.07.015. View

12.

Damiani C, Ricci I, Crotti E, Rossi P, Rizzi A, Scuppa P . Paternal transmission of symbiotic bacteria in malaria vectors. Curr Biol. 2008; 18(23):R1087-8. DOI: 10.1016/j.cub.2008.10.040. View

13.

Charan S, Pawar K, Severson D, Patole M, Shouche Y . Comparative analysis of midgut bacterial communities of Aedes aegypti mosquito strains varying in vector competence to dengue virus. Parasitol Res. 2013; 112(7):2627-37. DOI: 10.1007/s00436-013-3428-x. View

14.

Osei-Poku J, Mbogo C, Palmer W, Jiggins F . Deep sequencing reveals extensive variation in the gut microbiota of wild mosquitoes from Kenya. Mol Ecol. 2012; 21(20):5138-50. DOI: 10.1111/j.1365-294X.2012.05759.x. View

15.

Caragata E, Rances E, Hedges L, Gofton A, Johnson K, ONeill S . Dietary cholesterol modulates pathogen blocking by Wolbachia. PLoS Pathog. 2013; 9(6):e1003459. PMC: 3694857. DOI: 10.1371/journal.ppat.1003459. View

16.

Rainey S, Shah P, Kohl A, Dietrich I . Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges. J Gen Virol. 2013; 95(Pt 3):517-530. DOI: 10.1099/vir.0.057422-0. View

17.

Paradkar P, Duchemin J, Voysey R, Walker P . Dicer-2-dependent activation of Culex Vago occurs via the TRAF-Rel2 signaling pathway. PLoS Negl Trop Dis. 2014; 8(4):e2823. PMC: 3998923. DOI: 10.1371/journal.pntd.0002823. View

18.

Blitvich B, Firth A . Insect-specific flaviviruses: a systematic review of their discovery, host range, mode of transmission, superinfection exclusion potential and genomic organization. Viruses. 2015; 7(4):1927-59. PMC: 4411683. DOI: 10.3390/v7041927. View

19.

Zhong C, Sun W, Ma Y, Zhu H, Yang P, Wei H . Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep. 2015; 5:10512. PMC: 4444975. DOI: 10.1038/srep10512. View

20.

Chandler J, Liu R, Bennett S . RNA shotgun metagenomic sequencing of northern California (USA) mosquitoes uncovers viruses, bacteria, and fungi. Front Microbiol. 2015; 6:185. PMC: 4371751. DOI: 10.3389/fmicb.2015.00185. View