The Entomopathogenic Fungus Beauveria Bassiana Activate Toll and JAK-STAT Pathway-controlled Effector Genes and Anti-dengue Activity in Aedes Aegypti

Overview

Journal Insect Biochem Mol Biol

Specialties Biochemistry
Biology
Molecular Biology

Date 2011 Dec 27

PMID 22198333

Citations 58

Authors

Yuemei Dong

James C Morton Jr

Jose Luis Ramirez

Jayme A Souza-Neto

George Dimopoulos

Affiliations

Soon will be listed here.

Abstract

Here we investigated the effect of Beauveria bassiana infection on the survival of Aedes aegypti mosquitoes and the modulation of their susceptibility to dengue virus infection. Application of B. bassiana caused a reduction in the life span of A. aegypti and hindered dengue virus replication in the mosquito midgut. Fungus infection induced the expression a variety anti-microbial and dengue virus restriction factor genes. Transient reverse genetic analyses showed that the JAK-STAT pathway is implicated anti-fungal defense of Aedes mosquitoes. Our data suggest that this B. bassiana-mediated anti-dengue activity is likely to be at least partly indirectly mediated through the activation of the mosquito's anti-dengue Toll and JAK-STAT pathways.

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