Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy

Overview

Journal Case Rep Nephrol

Publisher Wiley

Specialty Nephrology

Date 2015 Sep 9

PMID 26347498

Citations 25

Authors

Rachele Escoli

Paulo Santos

Sequeira Andrade

Fernanda Carvalho

Affiliations

Soon will be listed here.

Abstract

Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms.

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