Deciphering Asthma Biomarkers with Protein Profiling Technology

Overview

Journal Int J Inflam

Publisher Wiley

Date 2015 Sep 9

PMID 26346739

Citations 5

Authors

Zhizhou Kuang

Jarad J Wilson

Shuhong Luo

Si-Wei Zhu

Ruo-Pan Huang

Affiliations

Soon will be listed here.

Abstract

Asthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic given that the disease consists of many variants, each with its own etiologic and pathophysiologic factors, including different cellular responses and inflammatory phenotypes. These facets make the rapid and accurate diagnosis (not to mention treatments) of asthma extremely difficult. Protein biomarkers can serve as powerful detection tools in both clinical and basic research applications. Recent endeavors from biomedical researchers have developed technical platforms, such as cytokine antibody arrays, that have been employed and used to further the global analysis of asthma biomarker studies. In this review, we discuss potential asthma biomarkers involved in the pathophysiologic process and eventual pathogenesis of asthma, how these biomarkers are being utilized, and how further testing methods might help improve the diagnosis and treatment strain that current asthma patients suffer.

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References

Woodruff P, Modrek B, Choy D, Jia G, Abbas A, Ellwanger A . T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009; 180(5):388-95. PMC: 2742757. DOI: 10.1164/rccm.200903-0392OC. View

Ishmael F . The inflammatory response in the pathogenesis of asthma. J Am Osteopath Assoc. 2011; 111(11 Suppl 7):S11-7. View

Moser B, Wolf M, Walz A, Loetscher P . Chemokines: multiple levels of leukocyte migration control. Trends Immunol. 2004; 25(2):75-84. DOI: 10.1016/j.it.2003.12.005. View

Ito T, Wang Y, Duramad O, Hori T, Delespesse G, Watanabe N . TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med. 2005; 202(9):1213-23. PMC: 2213234. DOI: 10.1084/jem.20051135. View

Wu D, Zhou J, Bi H, Li L, Gao W, Huang M . CCL11 as a potential diagnostic marker for asthma?. J Asthma. 2014; 51(8):847-54. DOI: 10.3109/02770903.2014.917659. View

Trinchieri G . Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol. 1995; 13:251-76. DOI: 10.1146/annurev.iy.13.040195.001343. View

Vazquez-Martin A, Colomer R, Menendez J . Protein array technology to detect HER2 (erbB-2)-induced 'cytokine signature' in breast cancer. Eur J Cancer. 2007; 43(7):1117-24. DOI: 10.1016/j.ejca.2007.01.037. View

Apter A . Advances in adult asthma diagnosis and treatment in 2013. J Allergy Clin Immunol. 2013; 133(1):49-56. DOI: 10.1016/j.jaci.2013.11.005. View

Wenzel S . Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012; 18(5):716-25. DOI: 10.1038/nm.2678. View

10.

Barnes P . The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest. 2008; 118(11):3546-56. PMC: 2575722. DOI: 10.1172/JCI36130. View

11.

Al-Shami A, Spolski R, Kelly J, Keane-Myers A, Leonard W . A role for TSLP in the development of inflammation in an asthma model. J Exp Med. 2005; 202(6):829-39. PMC: 2212950. DOI: 10.1084/jem.20050199. View

12.

Petering H, Hochstetter R, Kimmig D, Smolarski R, Kapp A, Elsner J . Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils. J Immunol. 1998; 160(2):555-8. View

13.

Fallon P, Ballantyne S, Mangan N, Barlow J, Dasvarma A, Hewett D . Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med. 2006; 203(4):1105-16. PMC: 2118283. DOI: 10.1084/jem.20051615. View

14.

Corry D, Folkesson H, Warnock M, Erle D, Matthay M, Wiener-Kronish J . Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996; 183(1):109-17. PMC: 2192426. DOI: 10.1084/jem.183.1.109. View

15.

Lemiere C, Chaboilliez S, Trudeau C, Taha R, Maghni K, Martin J . Characterization of airway inflammation after repeated exposures to occupational agents. J Allergy Clin Immunol. 2000; 106(6):1163-70. DOI: 10.1067/mai.2000.111235. View

16.

Chandra H, Reddy P, Srivastava S . Protein microarrays and novel detection platforms. Expert Rev Proteomics. 2011; 8(1):61-79. DOI: 10.1586/epr.10.99. View

17.

Chetta A, Zanini A, Foresi A, Del Donno M, Castagnaro A, DIppolito R . Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am J Respir Crit Care Med. 2002; 167(5):751-7. DOI: 10.1164/rccm.200207-710OC. View

18.

Ponath P, Qin S, Ringler D, Clark-Lewis I, Wang J, Kassam N . Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest. 1996; 97(3):604-12. PMC: 507095. DOI: 10.1172/JCI118456. View

19.

Wu W, Bleecker E, Moore W, Busse W, Castro M, Chung K . Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol. 2014; 133(5):1280-8. PMC: 4038417. DOI: 10.1016/j.jaci.2013.11.042. View

20.

Coleman J, Naik C, Holguin F, Ray A, Ray P, Trudeau J . Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset. Thorax. 2012; 67(12):1061-6. PMC: 3652589. DOI: 10.1136/thoraxjnl-2012-201634. View