Pediatric HIV-HBV Coinfection in Lusaka, Zambia: Prevalence and Short-Term Treatment Outcomes

Overview

Journal J Trop Pediatr

Specialties Pediatrics
Tropical Medicine

Date 2015 Sep 5

PMID 26338421

Citations 9

Authors

Kathryn Peebles

Lweendo Nchimba

Roma Chilengi

Carolyn Bolton Moore

Mwangelwa Mubiana-Mbewe

Michael J Vinikoor

Affiliations

Soon will be listed here.

Abstract

Hepatitis B virus (HBV) is endemic in Africa, where it may occur as an HIV coinfection. Data remain limited on HIV-HBV epidemiology in Africa, particularly in children. Using programmatic data from pediatric HIV clinics in Lusaka, Zambia during 2011-2014, we analyzed the prevalence of chronic HBV coinfection (defined as a single positive hepatitis B surface antigen [HBsAg] test) and its impact on immune recovery and liver enzyme elevation (LEE) during the first year of antiretroviral therapy. Among 411 children and adolescents, 10.4% (95% confidence interval, 7.6-14.1) had HIV-HBV. Coinfected patients were more likely to have World Health Organization stage 3/4, LEE and CD4 <14% at care entry (all p < 0.05). During treatment, CD4 increases and LEE incidence were similar by HBsAg status. HBsAg positivity decreased (11.8% vs. 6.6%; p = 0.24) following HBV vaccine introduction. These findings support screening pediatric HIV patients in Africa for HBV coinfection. Dedicated cohorts are needed to assess long-term outcomes of coinfection.

Citing Articles

Hepatitis B Virus in West African Children: Systematic Review and Meta-Analysis of HIV and Other Factors Associated with Hepatitis B Infection.

Fofana D, Somboro A, Maiga M, Kampo M, Diakite B, Cissoko Y Int J Environ Res Public Health. 2023; 20(5).

PMID: 36901164 PMC: 10002029. DOI: 10.3390/ijerph20054142.

Evaluation of Clinical Biomarkers Related to CD4 Recovery in HIV-Infected Patients-5-Year Observation.

Lembas A, Zaleski A, Mikula T, Dyda T, Stanczak W, Wiercinska-Drapalo A Viruses. 2022; 14(10).

PMID: 36298842 PMC: 9607521. DOI: 10.3390/v14102287.

Hepatitis B virus drug resistance mutations in HIV/HBV co-infected children in Windhoek, Namibia.

Tamandjou Tchuem C, Brandt L, Nel E, Cotton M, Matthews P, Kaindjee-Tjituka F PLoS One. 2020; 15(9):e0238839.

PMID: 32915862 PMC: 7485811. DOI: 10.1371/journal.pone.0238839.

HIV, syphilis and hepatitis B coinfections in Mkushi, Zambia: a cross-sectional study.

Katamba C, Chungu T, Lusale C F1000Res. 2020; 8:562.

PMID: 32802310 PMC: 7417957. DOI: 10.12688/f1000research.17983.2.

Prevalence and burden of HBV co-infection among people living with HIV: A global systematic review and meta-analysis.

Platt L, French C, McGowan C, Sabin K, Gower E, Trickey A J Viral Hepat. 2019; 27(3):294-315.

PMID: 31603999 PMC: 7383613. DOI: 10.1111/jvh.13217.

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