Estrogenicity of Novel Phase I and Phase II Metabolites of Zearalenone and Cis-zearalenone

Overview

Journal Toxicon

Specialty Toxicology

Date 2015 Sep 4

PMID 26335359

Citations 24

Authors

Sarah S Drzymala

Jennifer Binder

Antje Brodehl

Martin Penkert

Mark Rosowski

Leif-Alexander Garbe

Matthias Koch

Affiliations

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Abstract

Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, α-cis-zearalenol and β-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone.

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