Cell-block Procedure in Endoscopic Ultrasound-guided-fine-needle-aspiration of Gastrointestinal Solid Neoplastic Lesions

Overview

Journal World J Gastrointest Endosc

Publisher Baishideng Publishing Group

Date 2015 Sep 1

PMID 26322154

Citations 10

Authors

Antonio Ieni

Valeria Barresi

Paolo Todaro

Rosario Alberto Caruso

Giovanni Tuccari

Affiliations

Soon will be listed here.

Abstract

In the present review we have analyzed the clinical applications of endoscopic ultrasound-guided-fine-needle-aspiration (EUS-FNA) and the methodological aspects obtained by cell-block procedure (CBP) in the diagnostic approach to the gastrointestinal neoplastic pathology. CBP showed numerous advantages in comparison to the cytologic routine smears; in particular, better preservation of cell architecture, achievement of routine haematoxylin-eosin staining equivalent to histological slides and possibility to perform immunohistochemistry or molecular analyses represented the most evident reasons to choose this method. Moreover, by this approach, the differential diagnosis of solid gastrointestinal neoplasias may be more easily achieved and the background of contaminant non-neoplastic gastrointestinal avoided. Finally, biological samples collected by EUS-FNA CBP-assisted should be investigated in order to identify and quantify further potential molecular markers.

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