Molecular and Biochemical Aspects of the Retina on Refraction

Overview

Journal Prog Mol Biol Transl Sci

Specialty Molecular Biology

Date 2015 Aug 28

PMID 26310159

Citations 26

Authors

Ranjay Chakraborty

Machelle T Pardue

Affiliations

Soon will be listed here.

Abstract

Mutant mouse models with specific visual pathway defects offer an advantage to comprehensively investigate the role of specific pathways/neurons involved in refractive development. In this review, we will focus on recent studies using mouse models that have provided insight into retinal pathways and neurotransmitters controlling refractive development. Specifically, we will examine the contributions of rod and cone photoreceptors and the ON and OFF retinal pathways to visually driven eye growth with emphasis on dopaminergic mechanisms.

Citing Articles

Natural Course of Refractive Error in Congenital Stationary Night Blindness: Implications for Myopia Treatment.

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PMID: 39625438 PMC: 11620013. DOI: 10.1167/iovs.65.14.9.

Loss of ON-Pathway Function in Mice Lacking Lrit3 Decreases Recovery From Lens-Induced Myopia.

Wilmet B, Michiels C, Zhang J, Callebert J, Sahel J, Picaud S Invest Ophthalmol Vis Sci. 2024; 65(11):18.

PMID: 39250117 PMC: 11385651. DOI: 10.1167/iovs.65.11.18.

Pupillary Light Reflex Reveals Melanopsin System Alteration in the Background of Myopia-26, the Female Limited Form of Early-Onset High Myopia.

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The Role of Retinal Dopamine D1 Receptors in Ocular Growth and Myopia Development in Mice.

Shu Z, Chen K, Wang Q, Wu H, Zhu Y, Tian R J Neurosci. 2023; 43(48):8231-8242.

PMID: 37751999 PMC: 10697406. DOI: 10.1523/JNEUROSCI.1196-23.2023.

Encephalopsin (OPN3) is required for normal refractive development and the GO/GROW response to induced myopia.

Linne C, Mon K, DSouza S, Jeong H, Jiang X, Brown D Mol Vis. 2023; 29:39-57.

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