Intracochlear Bleeding Enhances Cochlear Fibrosis and Ossification: An Animal Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Aug 27

PMID 26308864

Citations 13

Authors

Kyeung A Ryu

Ah-Ra Lyu

Heesung Park

Jin Woong Choi

Gang Min Hur

Yong-Ho Park

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the effects of intracochlear bleeding during cochleostomy on cochlear inflammatory response and residual hearing in a guinea pig animal model. Auditory brainstem response threshold shifts were greater in blood injected ears (p<0.05). Interleukin-1β, interleukin-10, tumor necrosis factor-α and nitric oxide synthase 2, cytokines that are related to early stage inflammation, were significantly increased in blood injected ears compared to normal and cochleostomy only ears at 1 day after surgery; with the increased IL-1β being sustained until 3 days after the surgery (p<0.05). Hair cells were more severely damaged in blood injected ears than in cochleostomy only ears. Histopathologic examination revealed more extensive fibrosis and ossification in blood injected ears than cochleostomy only ears. These results show that intracochlear bleeding enhanced cochlear inflammation resulting in increased fibrosis and ossification in an experimental animal model.

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