Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2015 Aug 27

PMID 26307974

Citations 42

Authors

Jun Wang

Yong-Xi Song

Bin Ma

Jia-Jun Wang

Jing-Xu Sun

Xiao-Wan Chen

Jun-Hua Zhao

Yu-Chong Yang

Zhen-Ning Wang

Affiliations

Soon will be listed here.

Abstract

Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

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