Regulation of Renal Phosphate Handling: Inter-organ Communication in Health and Disease

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2015 Aug 23

PMID 26296817

Citations 15

Authors

Sawako Tatsumi

Atsumi Miyagawa

Ichiro Kaneko

Yuji Shiozaki

Hiroko Segawa

Ken-Ichi Miyamoto

Affiliations

Soon will be listed here.

Abstract

In this review, we focus on the interconnection of inorganic phosphate (Pi) homeostasis in the network of the bone-kidney, parathyroid-kidney, intestine-kidney, and liver-kidney axes. Such a network of organ communication is important for body Pi homeostasis. Normalization of serum Pi levels is a clinical target in patients with chronic kidney disease (CKD). Particularly, disorders of the fibroblast growth factor 23/klotho system are observed in early CKD. Identification of phosphaturic factors from the intestine and liver may enhance our understanding of body Pi homeostasis and Pi metabolism disturbances in CKD patients.

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