Tissue Instruction for Migration and Retention of TRM Cells

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2015 Aug 19

PMID 26282885

Citations 66

Authors

Norifumi Iijima

Akiko Iwasaki

Affiliations

Soon will be listed here.

Abstract

During infection, a subset of effector T cells seeds the lymphoid and non-lymphoid tissues and gives rise to tissue-resident memory T cells (TRM). Recent findings have provided insight into the molecular and cellular mechanisms underlying tissue instruction of TRM cell homing, as well as the programs involved in their retention and maintenance. We review these findings here, highlighting both common features and distinctions between CD4 TRM and CD8 TRM cells. In this context we examine the role of memory lymphocyte clusters (MLCs), and propose that the MLCs serve as an immediate response center consisting of TRM cells on standby, capable of detecting incoming pathogens and mounting robust local immune responses to contain and limit the spread of infectious agents.

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