Behavior of Parasite-specific Effector CD8+ T Cells in the Brain and Visualization of a Kinesis-associated System of Reticular Fibers

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2009 Jan 27

PMID 19167248

Citations 104

Authors

Emma H Wilson

Tajie H Harris

Paulus Mrass

Beena John

Elia D Tait

Gregory F Wu

Marion Pepper

E John Wherry

Florence Dzierzinski

David Roos

Philip G Haydon

Terri M Laufer

Wolfgang Weninger

Christopher A Hunter

Affiliations

Soon will be listed here.

Abstract

To understand lymphocyte behavior in the brain, we used two-photon microscopy to visualize effector CD8(+) T cells during toxoplasmic encephalitis. These cells displayed multiple behaviors with two distinct populations of cells apparent: one with a constrained pattern of migration and one with a highly migratory subset. The proportion of these populations varied over time associated with changes in antigen availability as well as T cell expression of the inhibitory receptor PD1. Unexpectedly, the movement of infiltrating cells was closely associated with an infection-induced reticular system of fibers. This observation suggests that, whereas in other tissues pre-existing scaffolds exist that guide lymphocyte migration, in the brain specialized structures are induced by inflammation that guide migration of T cells in this immune-privileged environment.

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